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Product Name: Acetamide,N-[(7S)-5,6,7,9-tetrahydro-10-hydroxy-1,2,3-trimethoxy-9-oxobenzo[a]heptalen-7-yl]-
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477-27-0

477-27-0 structure

477-27-0 structure

Name: Colchiceine
Chemical Name: Colchiceine
CAS Number: 477-27-0
Molecular Formula: C₂₁H₂₃NO₆
Molecular Weight: 385.41000
Create Date: 2018-10-01 15:47:19
Modify Date: 2024-01-02 18:38:46

Name	Colchiceine
Synonyms	colchiceine

Density	1.31g/cm3
Boiling Point	731.5ºC at 760mmHg
Melting Point	172-174ºC
Molecular Formula	C₂₁H₂₃NO₆
Molecular Weight	385.41000
Flash Point	396.2ºC
Exact Mass	385.15300
PSA	94.09000
LogP	2.95950
Vapour Pressure	1.83E-22mmHg at 25°C
Index of Refraction	1.61

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0520000

CHEMICAL NAME :: Colchiceine

CAS REGISTRY NUMBER :: 477-27-0

BEILSTEIN REFERENCE NO. :: 2824078

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C21-H23-N-O6

MOLECULAR WEIGHT :: 385.45

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JMV1 NQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 43 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 84 mg/kg

TOXIC EFFECTS :: Blood - hemorrhage

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Mutation test systems - not otherwise specified

TYPE OF TEST :: Sperm Morphology

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 250 nmol/L

REFERENCE :: AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925- Volume(issue)/page/year: 137,779,1990

Hazard Codes	T+
HS Code	2924299090

3482-37-9 structure

3482-37-9

108-24-7 structure

108-24-7

~%

477-27-0 structure

477-27-0

Literature: Roesner, Manfred; Capraro, Hans-Georg; Jacobson, Arthur E.; Atwell, Louise; Brossi, Arnold; et al. Journal of Medicinal Chemistry, 1981 , vol. 24, # 3 p. 257 - 261

73307-44-5 structure

73307-44-5

~%

477-27-0 structure

477-27-0

Literature: Corrodi; Hardegger Helvetica Chimica Acta, 1957 , vol. 40, p. 193,198, 199

102419-93-2 structure

102419-93-2

~%

477-27-0 structure

477-27-0

Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521

209810-38-8 structure

209810-38-8

~%

477-27-0 structure

477-27-0

Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521

102491-70-3 structure

102491-70-3

~%

477-27-0 structure

477-27-0

Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521

102491-74-7 structure

102491-74-7

~%

477-27-0 structure

477-27-0

Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521

102491-72-5 structure

102491-72-5

~%

477-27-0 structure

477-27-0

Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521

102419-92-1 structure

102419-92-1

~%

477-27-0 structure

477-27-0

Literature: Dumont; Brossi; Silverton Journal of Organic Chemistry, 1986 , vol. 51, # 13 p. 2515 - 2521

7469-68-3 structure

7469-68-3

~%

477-27-0 structure

477-27-0

Literature: Corrodi; Hardegger Helvetica Chimica Acta, 1957 , vol. 40, p. 193,198, 199

Precursor 10
3482-37-9 108-24-7 73307-44-5 102419-93-2
209810-38-8 102491-70-3 102491-74-7 102491-72-5
102419-92-1 7469-68-3
DownStream 10
3476-50-4 3482-37-9 477-30-5 64-86-8
518-12-7 518-11-6 7404-91-3 7336-40-5
75491-24-6 75488-69-6

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%