BioBioPha
China
Product Name: (-)-Borneol
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: (-)-Borneol
Price: ￥478.0/5mg ￥178.0/25g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: (-)-Borneol
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: (-)-borneol
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

464-45-9

464-45-9 structure

464-45-9 structure

Name: (-)-Borneol
Chemical Name: (-)-borneol
CAS Number: 464-45-9
Molecular Formula: C₁₀H₁₈O
Molecular Weight: 154.249
Catalog: Natural product Moss
Create Date: 2018-09-28 20:05:24
Modify Date: 2024-01-02 22:01:47
(-)-Borneol has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.

Name	(-)-borneol
Synonyms	L-BORNEOL l-2-Bornanol Borneol endo-(1S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol endo-2-hydroxycamphane 2-Camphanol Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, (1S-endo)- L(-)-Borneol Bicyclo[2.2.1]heptan-2-ol, 1,7,7-trimethyl-, (1S,2R,4S)- (1S,2R,4S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol [(1s)-endo]-(-)-borneol 2-Bornanol, endo- EINECS 207-353-1 (1S-endo)-1,7,7-Trimethylbicyclo(2.2.1)heptan-2-ol (-)-Borneol (−)-Borneol Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-, (1S,2R,4S)- FEMA 2157 (1S)-endo-(-)-Borneol BICYCLO(2.2.1)HEPTAN-2-OL, 1,7,7-TRIMETHYL-, (1S-ENDO)- 2-bornanol Bornan-2-ol MFCD00003759 (？)-Borneol endo-2-Bornanol Linderol endo-1,7,7-trimethylbicyclo[2.2.1]heptan-2-ol Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-, endo- endo-2-camphanol ngaicamphor bornel

Description	(-)-Borneol has a highly efficacious positive modulating action at GABA receptor with an EC50 of 237 μM.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Signaling Pathways >> Neuronal Signaling >> GABA Receptor Research Areas >> Neurological Disease Natural Products >> Terpenoids and Glycosides
Target	EC50: 237 μM (GABA receptor)[1]
In Vitro	(-)-Borneol is an enantiomer of (+)-Borneol. (+)-Borneol is a natural bicyclic monoterpene used for analgesia and anesthesia in traditional Chinese medicine; enhances GABA receptor activity with an EC50 of 248 μM. At high concentrations (>1.5 mM), (-)-Borneol directly activates GABAA receptors producing 84% of the maximal GABA response indicative of a weak partial agonist action. (-)-Borneol produces dose-dependent positive modulation of the Cl- conductance generated by extremely low dose GABA at α1β2γ2L GABAA receptors[1].
References	[1]. IGranger RE, et al. (+)- And (-)-borneol: efficacious positive modulators of GABA action at human recombinantalpha1beta2gamma2L GABA(A) receptors. Biochem Pharmacol. 2005 Apr 1;69(7):1101-11.

Density	1.0±0.1 g/cm3
Boiling Point	212.0±0.0 °C at 760 mmHg
Melting Point	206-209 °C
Molecular Formula	C₁₀H₁₈O
Molecular Weight	154.249
Flash Point	65.6±0.0 °C
Exact Mass	154.135757
PSA	20.23000
LogP	2.71
Vapour density	5.31 (vs air)
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.502
Water Solubility	INSOLUBLE

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DT5095000

CHEMICAL NAME :: Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-, (1S-endo)-

CAS REGISTRY NUMBER :: 464-45-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H18-O

MOLECULAR WEIGHT :: 154.28

WISWESSER LINE NOTATION :: L55 ATJ A1 A1 B1 CQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,655,1978 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,655,1978

Symbol	GHS02, GHS07
Signal Word	Warning
Hazard Statements	H228-H317
Precautionary Statements	P210-P280
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	F:Flammable;
Risk Phrases	R11
Safety Phrases	S16-S36/37
RIDADR	UN 1312 4.1/PG 3
WGK Germany	2
RTECS	DT5095000
Packaging Group	III
Hazard Class	4.1
HS Code	29061900

Precursor 5
100703-54-6 54384-77-9 100703-55-7 100837-41-0
100703-52-4
DownStream 10
560-09-8 79-92-5 4443-48-5 4501-58-0
464-48-2 93-53-8 81115-69-7 81115-66-4
20279-31-6 20279-25-8

HS Code	2906199090
Summary	2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%