524-14-1

524-14-1 structure

Name: Malonyl CoA
Chemical Name: malonyl-CoA
CAS Number: 524-14-1
Molecular Formula: C₂₄H₃₈N₇O₁₉P₃S
Molecular Weight: 853.58000
Catalog: Research Areas Metabolic Disease
Create Date: 2017-05-03 01:38:58
Modify Date: 2024-01-06 12:23:55
Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1[1][2].

Name	malonyl-CoA
Synonyms	2,6-Dioxo-cyclohexancarbaldehyd 2-formyl-1,3-cyclohexanedione 2,6-dioxo-cyclohexanecarbaldehyde S-(HYDROGEN MALONYL)COENZYME A 3-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-3-oxopropanoicacid S-(HYDROGEN MALONYL)COENZYME A

Description	Malonyl CoA is a substrate for fatty acid biosynthesis and an inhibitor of fatty acid oxidation. Malonyl CoA is also a reversible inhibitor of mitochondrial carnitine palmitoyltransferase (CPT) 1[1][2].
Related Catalog	Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	丙二酰辅酶A (20 μM，6分钟) 抑制 MCF-7 细胞 CPT1 活性 (降低 75%)[2]. 丙二酰辅酶A (0-3 μM) 抑制雌性大鼠肝线粒体中的 CPT1 活性[3].
References	[1]. Folmes CD, et L. Role of malonyl-CoA in heart disease and the hypothalamic control of obesity. Cardiovasc Res. 2007 Jan 15;73(2):278-87. [2]. Thupari JN, et al. Fatty acid synthase inhibition in human breast cancer cells leads to malonyl-CoA-induced inhibition of fatty acid oxidation and cytotoxicity. Biochem Biophys Res Commun. 2001 Jul 13;285(2):217-23. [3]. Zammit VA. Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro. Biochem J. 1983 Mar 15;210(3):953-6.