921-62-0

921-62-0 structure

Name: 6-Phosphogluconic acid
Chemical Name: 6-phospho-D-gluconic acid
CAS Number: 921-62-0
Molecular Formula: C₆H₁₃O₁₀P
Molecular Weight: 276.135
Catalog: Research Areas Metabolic Disease
Create Date: 2018-07-23 12:32:04
Modify Date: 2024-01-02 14:41:25
6-Phosphogluconic acid is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid is an endogenous metabolite[1][2].

Name	6-phospho-D-gluconic acid
Synonyms	6-PHOSPHOGLUCONIC ACID BARIUM SALT EINECS 213-069-9 6-Phosphogluconate Barium Salt Hydrate MFCD00066440 6-O-Phosphonohexonic acid Hexonic acid, 6-(dihydrogen phosphate)

Description	6-Phosphogluconic acid is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid is an endogenous metabolite[1][2].
Related Catalog	Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	6-Phosphogluconic acid (0.5-2.0 mM) completely inhibits the activity of PGI with glucose 6-phosphate (0.05- 0.5 mM) as the substrate[1].
References	[1]. Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52(5):1348-52. [2]. Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22(5):585-600.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302 + H332
Precautionary Statements	P261-P301 + P312 + P330-P304 + P340 + P312
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/22
Safety Phrases	28
RIDADR	UN 1564 6.1/PG 3
Packaging Group	III