37178-37-3
37178-37-3 structure
- Name: Etilevodopa
- Chemical Name: ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate
- CAS Number: 37178-37-3
- Molecular Formula: C11H15NO4
- Molecular Weight: 225.24100
- Catalog: Research Areas Neurological Disease
- Create Date: 2016-07-07 17:16:58
- Modify Date: 2024-01-07 13:01:39
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Etilevodopa (L-Dopa ethyl ester), an ethyl-ester prodrug of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable prodrug as it facilitates CNS penetration and delivers dopamine[1][2][3].
| Name | ethyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate |
|---|---|
| Synonyms |
3-hydroxy-L-tyrosine ethyl ester
levodopa ethyl ester O-Ethyl-DOPA TV-1203 Etilevodopa UNII-895X917GYE 3,4-dihydroxy-L-phenylalanine ethyl ester Etilevodopa [USAN:INN] L-DOPA ethyl ester |
| Description | Etilevodopa (L-Dopa ethyl ester), an ethyl-ester prodrug of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable prodrug as it facilitates CNS penetration and delivers dopamine[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Etilevodopa (L-Dopa ethyl ester) passes unchanged through the stomach to the duodenum, where it is rapidly hydrolyzed by local esterases to Levodopa and ethanol, and is subsequently absorbed into the blood stream as Levodopa[1]. Compared with standard Levodopa, Etilevodopa has greater solubility in the stomach, faster passage to the small intestine, and a shortened time to maximum Levodopa concentration[2]. |
| References |
| Density | 1.278g/cm3 |
|---|---|
| Boiling Point | 394.2ºC at 760 mmHg |
| Molecular Formula | C11H15NO4 |
| Molecular Weight | 225.24100 |
| Flash Point | 192.2ºC |
| Exact Mass | 225.10000 |
| PSA | 92.78000 |
| LogP | 1.23100 |
| Index of Refraction | 1.581 |
| Storage condition | 2-8°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | 22-36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2922509090 |
|
~89%
37178-37-3 |
| Literature: Yissum Research Development Company of the Hebrew University of Jerusalem; Teva Pharmaceutical Industries Ltd. Patent: US5607969 A1, 1997 ; |
|
~99%
37178-37-3 |
| Literature: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; SATYAMURTHY, Nagichettiar; BARRIO, Jorge, R. Patent: WO2010/117435 A2, 2010 ; Location in patent: Page/Page column 18 ; |
| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |