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88058-88-2

88058-88-2 structure
88058-88-2 structure
  • Name: Naxagolide
  • Chemical Name: (4aR,10bR)-4-propyl-2,3,4a,5,6,10b-hexahydrobenzo[h][1,4]benzoxazin-9-ol
  • CAS Number: 88058-88-2
  • Molecular Formula: C15H21NO2
  • Molecular Weight: 247.333
  • Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
  • Create Date: 2018-03-14 08:00:00
  • Modify Date: 2024-01-02 19:21:46
  • Naxagolide ((+)-PHNO; Dopazinol) is a potent dopamine D2 (Dopamine Receptor) agonist. Naxagolide has the potential for the research of parkinson's disease (PD)[1][2].

Name (4aR,10bR)-4-propyl-2,3,4a,5,6,10b-hexahydrobenzo[h][1,4]benzoxazin-9-ol
Synonyms (+)-PHNO
4-Propyl-9-hydroxy-1,2,3,4a,5,6-hexahydronaphthoxazine
(+)-trans-1a,2,3,4a,5,6-Hexahydro-9-hydroxy-4-propyl-4H-naphth-[1,2-b]-1,4-oxazine
Naxagolida
dopazinol
(4aR,10bR)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol
Naxagolide
(+)-4-Propyl-9-hydroxynaphthoxazine
2H-Naphth[1,2-b]-1,4-oxazin-9-ol, 3,4,4a,5,6,10b-hexahydro-4-propyl-, (4aR,10bR)-
(4aR)-trans-3,4,4a,5,6,10b-Hexahydro-4-propyl-2H-naphth[1,2-b]-1,4-oxazin-9-ol
PHNO
Description Naxagolide ((+)-PHNO; Dopazinol) is a potent dopamine D2 (Dopamine Receptor) agonist. Naxagolide has the potential for the research of parkinson's disease (PD)[1][2].
Related Catalog
Target

D2 Receptor

In Vitro 在体外,Naxagolide ((+)-PHNO) 抑制大鼠纹状体膜上的 [3H]apomorphine (IC50 = 23 nM) 或 [3 H]spiperone (IC50 = 55 nM)[1]。
In Vivo 在小鼠中,Naxagolide ((+)-PHNO) 在单侧尾部切除的动物中产生体温过低 (13 μg/kg i.p.) 和姿势不对称 (4 μg/kg i.p.)[1]。 在大鼠中,Naxagolide ((+)-PHNO) 在 6-羟基多巴胺损伤的动物中产生刻板印象(10 μg/kg i.p.)和对侧转向(5 μg/kg i.p.),持续 1 至 3 小时[1] 。
References

[1]. G E Martin, et al. Pharmacologic profile of a novel potent direct-acting dopamine agonist, (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO]. J Pharmacol Exp Ther. 1984 Sep;230(3):569-76.  

[2]. E F Domino, et al. Relative potency and efficacy of some dopamine agonists with varying selectivities for D1 and D2 receptors in MPTP-induced hemiparkinsonian monkeys. J Pharmacol Exp Ther. 1993 Jun;265(3):1387-91.  

Density 1.1±0.1 g/cm3
Boiling Point 391.7±42.0 °C at 760 mmHg
Molecular Formula C15H21NO2
Molecular Weight 247.333
Flash Point 190.7±27.9 °C
Exact Mass 247.157227
PSA 32.70000
LogP 2.55
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.553
HS Code 2934999090
HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%