Name | (4aR,10bR)-4-propyl-2,3,4a,5,6,10b-hexahydrobenzo[h][1,4]benzoxazin-9-ol |
---|---|
Synonyms |
(+)-PHNO
4-Propyl-9-hydroxy-1,2,3,4a,5,6-hexahydronaphthoxazine (+)-trans-1a,2,3,4a,5,6-Hexahydro-9-hydroxy-4-propyl-4H-naphth-[1,2-b]-1,4-oxazine Naxagolida dopazinol (4aR,10bR)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-naphtho[1,2-b][1,4]oxazin-9-ol Naxagolide (+)-4-Propyl-9-hydroxynaphthoxazine 2H-Naphth[1,2-b]-1,4-oxazin-9-ol, 3,4,4a,5,6,10b-hexahydro-4-propyl-, (4aR,10bR)- (4aR)-trans-3,4,4a,5,6,10b-Hexahydro-4-propyl-2H-naphth[1,2-b]-1,4-oxazin-9-ol PHNO |
Description | Naxagolide ((+)-PHNO; Dopazinol) is a potent dopamine D2 (Dopamine Receptor) agonist. Naxagolide has the potential for the research of parkinson's disease (PD)[1][2]. |
---|---|
Related Catalog | |
Target |
D2 Receptor |
In Vitro | 在体外,Naxagolide ((+)-PHNO) 抑制大鼠纹状体膜上的 [3H]apomorphine (IC50 = 23 nM) 或 [3 H]spiperone (IC50 = 55 nM)[1]。 |
In Vivo | 在小鼠中,Naxagolide ((+)-PHNO) 在单侧尾部切除的动物中产生体温过低 (13 μg/kg i.p.) 和姿势不对称 (4 μg/kg i.p.)[1]。 在大鼠中,Naxagolide ((+)-PHNO) 在 6-羟基多巴胺损伤的动物中产生刻板印象(10 μg/kg i.p.)和对侧转向(5 μg/kg i.p.),持续 1 至 3 小时[1] 。 |
References |
Density | 1.1±0.1 g/cm3 |
---|---|
Boiling Point | 391.7±42.0 °C at 760 mmHg |
Molecular Formula | C15H21NO2 |
Molecular Weight | 247.333 |
Flash Point | 190.7±27.9 °C |
Exact Mass | 247.157227 |
PSA | 32.70000 |
LogP | 2.55 |
Vapour Pressure | 0.0±0.9 mmHg at 25°C |
Index of Refraction | 1.553 |
HS Code | 2934999090 |
---|
Precursor 6 | |
---|---|
DownStream 0 |
HS Code | 2934999090 |
---|---|
Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |