Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Isonicotinic acid
Price: ￥218.0/500g ￥88.0/100g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Isonicotinic acid; Isoniazid, 4-pyridinecarboxylic acid, p-pyridinecarboxylic acid, 4-Picolinic acid
Price: $150.0/100mg $300.0/250mg $600.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Isonicotinic acid
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

ANHUI DEXINJIA BIOPHARM CO.,LTD
China
Product Name: Isonicotinic acid
Price: ￥Inquiry/1kg ￥Inquiry/25kg ￥Inquiry/100kg ￥Inquiry/1ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Haiyao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: isonicotinic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

55-22-1

55-22-1 structure

Name: Isonicotinic acid
Chemical Name: isonicotinic acid
CAS Number: 55-22-1
Molecular Formula: C₆H₅NO₂
Molecular Weight: 123.109
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Pyridine derivative
Create Date: 2018-05-12 08:00:00
Modify Date: 2024-01-02 13:57:47
Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C[1].

Name	isonicotinic acid
Synonyms	EINECS 200-228-2 4-Pyridinecarboxylic acid g-Pyridinecarboxylic Acid Pyridine-4-carboxylic acid MFCD00006429 g-picolinic acid Isonicotinic acid

Description	Isonicotinic acid is a metabolite of Isoniazid. Isoniazid is converted to Isonicotinic acid by hydrazinolysis, with the Isoniazid to Isonicotinic acid biotransformation also to be catalyzed by cytochrome P450 (CYP) enzymes, e.g., CYP2C[1].
Related Catalog	Research Areas >> Others
References	[1]. Seng KY, et al. Population pharmacokinetic analysis of isoniazid, acetylisoniazid, and isonicotinic acid in healthy volunteers. Antimicrob Agents Chemother. 2015 Nov;59(11):6791-9.

Density	1.3±0.1 g/cm3
Boiling Point	396.0±15.0 °C at 760 mmHg
Melting Point	≥300 °C(lit.)
Molecular Formula	C₆H₅NO₂
Molecular Weight	123.109
Flash Point	193.3±20.4 °C
Exact Mass	123.032028
PSA	50.19000
LogP	0.54
Vapour Pressure	0.0±1.0 mmHg at 25°C
Index of Refraction	1.571
Storage condition	-20°C
Water Solubility	5.2 g/L (20 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NS1103000

CHEMICAL NAME :: Isonicotinic acid

CAS REGISTRY NUMBER :: 55-22-1

LAST UPDATED :: 199709

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C6-H5-N-O2

MOLECULAR WEIGHT :: 123.12

WISWESSER LINE NOTATION :: T6NJ DVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,481,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3123 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,481,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 436 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)

REFERENCE :: PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,481,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 23,1343,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6268 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1822 (estimated) No. of Female Employees: 272 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	NS1103000
HS Code	2933399090

Precursor 10
1453-82-3 108-89-4 13602-12-5 54-85-3
100-48-1 872-85-5 71653-47-9 638203-02-8
54751-01-8 586-95-8
DownStream 10
36209-51-5 54-85-3 4329-75-3 38634-05-8
490-11-9 33972-97-3 54751-01-8 59290-82-3
586-95-8 108-89-4

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

55-22-1	59097-06-2
100-48-1	1211520-08-9
1240618-14-7	46342-79-4
51362-08-4	29071-75-8
10354-58-2	4013-73-4