Name | (4-nitrophenyl) 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate |
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Synonyms |
1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, 4-nitrophenyl ester, (3aS,4S,6aR)-
Biotin-p-nitrophenyl ester D-biotin 4-nitrophenyl ester MFCD00005540 D-Biotin P-Nitrophenyl Ester (+)-Biotin 4-nitrophenyl ester Biotinyl-4-nitrophenyl ester D-(+)-biotin 2-nitrophenyl ester 4-Nitrophenyl 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate BNP,D-Biotin 4-nitrophenyl ester 4-Nitrophenyl (+)-biotinate |
Description | (+)-Biotin-ONP is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
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Related Catalog | |
Target |
Alkyl-Chain |
In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 642.9±50.0 °C at 760 mmHg |
Melting Point | 163-165ºC |
Molecular Formula | C16H19N3O5S |
Molecular Weight | 365.404 |
Flash Point | 342.6±30.1 °C |
Exact Mass | 365.104553 |
PSA | 138.55000 |
LogP | 1.89 |
Vapour Pressure | 0.0±1.9 mmHg at 25°C |
Index of Refraction | 1.584 |
Safety Phrases | S22-S24/25 |
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~% 33755-53-2 |
Literature: Journal of the American Chemical Society, , vol. 99, # 1 p. 235 - 239 |
~% 33755-53-2 |
Literature: Journal of the American Chemical Society, , vol. 99, # 1 p. 235 - 239 |
~% 33755-53-2 |
Literature: Journal of the American Chemical Society, , vol. 99, # 1 p. 235 - 239 |