94376-75-7

94376-75-7 structure

Name: Bis-PEG7-acid
Chemical Name: 3-(2-{2-[2-(2-{2-[2-(2-Carboxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}-ethoxy)propionic acid
CAS Number: 94376-75-7
Molecular Formula: C₁₈H₃₄O₁₁
Molecular Weight: 426.45600
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2017-12-03 13:43:04
Modify Date: 2024-01-10 11:05:28
Bis-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name	3-(2-{2-[2-(2-{2-[2-(2-Carboxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethoxy}-ethoxy)propionic acid
Synonyms	HOOCCH2CH2-PEG6-CH2CH2COOH α,ω-Dipropionic acid hexaethylene glycol Alpha,ω-dipropionic acid hexaethylene glycol

Description	Bis-PEG7-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG6-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Marc Stefan ROBILLARD, et al. Tetrazines for high click conjugation yield in vivo and high click release yield. WO2019212356A1