5502-96-5
5502-96-5 structure
- Name: NAADP tetrasodium salt
- Chemical Name: nicotinic acid-adenine dinucleotide phosphate
- CAS Number: 5502-96-5
- Molecular Formula: C21H27N6O18P3
- Molecular Weight: 744.39
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2017-08-01 19:38:34
- Modify Date: 2024-01-10 19:33:12
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NAADP, a nucleotide, is a Ca2+-mobilizing second messenger. NAADP is essential for initiation of Ca2+ signaling[1][2].
| Name | nicotinic acid-adenine dinucleotide phosphate |
|---|---|
| Synonyms | NAADP tetrasodium salt |
| Description | NAADP, a nucleotide, is a Ca2+-mobilizing second messenger. NAADP is essential for initiation of Ca2+ signaling[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | NAADP tetrasodium (2.5-10 μM) 诱导细胞毒性 T 淋巴细胞中酸性细胞内储存的 Ca2+ 释放[2]。 NAADP tetrasodium (10 μM，30 分钟) 刺激细胞毒性 T 淋巴细胞中的溶细胞颗粒胞吐作用[2]。 |
| In Vivo | NAADP (0.181 mg/kg, i.v.) promotes autophagosome formation and protects the hepatocytes from injury in mice induced by LPS/GalN[3]. Animal Model: LPS/GalN induced liver injury mice model[3] Dosage: 3-30 mg/kg Administration: 0.181 mg/kg, i.v. Result: Promoted autophagosome formation in in hepatocytes. Showed higher levels of LC3II, p62, ATG5, and ATG7 in hepatocytes. |
| References |
[1]. Walseth TF, et al: From Discovery to Mechanism. Front Immunol. 2021 Sep 7;12:703326. |
| Molecular Formula | C21H27N6O18P3 |
|---|---|
| Molecular Weight | 744.39 |
| Exact Mass | 743.07500 |
| PSA | 397.05000 |
| Storage condition | 20°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |