DC Chemicals Limited
China
Product Name: 13-Dihydrodoxorubicin
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54193-28-1

54193-28-1 structure

54193-28-1 structure

Name: Doxorubicinol
Chemical Name: adriamycinol
CAS Number: 54193-28-1
Molecular Formula: C₂₇H₃₁NO₁₁
Molecular Weight: 545.54
Create Date: 2016-02-17 16:08:42
Modify Date: 2024-01-02 06:55:12
Doxorubicinol, a potent inhibitor of the cardiac sarcoplasmic reticulum calcium pump, inhibits systolic myocardial function in isolated heart muscle. Doxorubicinol inhibits tumor cell growth and has cardiotoxicity.

Name	adriamycinol
Synonyms	14-hydroxydaunomycinone adriamycinaglycone 8-glycoloyl-7,8,9,10-tetrahydro-6,8,10,11-tetrahydroxy-1-methoxy-5,12-Naphthacenedione doxorubicin aglycone Doxorubicinol Adriamycin-aglycon (1S,3S)-3-[(1S)-1,2-Dihydroxyethyl]-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside Epirubicin aglycone doxorubicin hydroxyaglycone 5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-8-[(1S)-1,2-dihydroxyethyl]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S,10S)- Epirubicin aglycon Doxorubicinone 13-dihydrodoxorubicin

Description	Doxorubicinol, a potent inhibitor of the cardiac sarcoplasmic reticulum calcium pump, inhibits systolic myocardial function in isolated heart muscle. Doxorubicinol inhibits tumor cell growth and has cardiotoxicity.
Related Catalog	Research Areas >> Cardiovascular Disease
In Vitro	Doxorubicinol 抑制分离的乳头肌的舒张功能（即增加静息压）[1]。 Doxorubicinol 在显著降低舒张功能的浓度下，阿霉素几乎完全消除钙泵活性[1]。 Doxorubicinol 抑制 Ca2+ 刺激的骨骼肌肌浆网的 ATP 酶活性，并消除犬和兔心脏制备物中肌膜的 Na+/K+-ATP 酶活性[1]。 Doxorubicinol 抑制 PANC-1 细胞的增殖，IC50 值为 35.4 μM，PD PaCa 细胞的 IC50 值为 44.5 μM，WD PaCa 细胞的 IC50 值为 49.5 μM[1]。
References	[1]. Olson RD, et al. Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol. Proc Natl Acad Sci U S A. 1988 May;85(10):3585-9.

Density	1.6±0.1 g/cm3
Boiling Point	828.7±65.0 °C at 760 mmHg
Molecular Formula	C₂₇H₃₁NO₁₁
Molecular Weight	545.54
Flash Point	455.0±34.3 °C
Exact Mass	545.189697
PSA	209.23000
LogP	2.01
Vapour Pressure	0.0±3.2 mmHg at 25°C
Index of Refraction	1.717

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QI9326000

CHEMICAL NAME :: 5,12-Naphthacenedione, 7,8,9,10-tetrahydro-10-((3-amino-2,3,6-trideoxy-alpha -L-lyxo- hexopyranosyl)oxy)-8-(1,2-dihdyroxyethyl)-1-methoxy-6 ,8,11-trihydroxy-, (8S-(8-alpha,8(R*), 10-alpha))-

CAS REGISTRY NUMBER :: 54193-28-1

LAST UPDATED :: 199706

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C27-H31-N-O11

MOLECULAR WEIGHT :: 545.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA damage

TEST SYSTEM :: Rodent - mouse Leukocyte

DOSE/DURATION :: 26900 nmol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 41,1006,1981

Precursor 0
DownStream 1
23214-92-8