139262-23-0

139262-23-0 structure

Name: Fmoc-Lys-OH hydrochloride
Chemical Name: (2S)-6-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid,hydrochloride
CAS Number: 139262-23-0
Molecular Formula: C₂₁H₂₅ClN₂O₄
Molecular Weight: 404.887
Catalog: Biochemical Amino acids and their derivatives Lysine derivative
Create Date: 2018-09-28 14:16:25
Modify Date: 2024-01-02 18:25:49
Fmoc-Lys-OH hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys-OH hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].

Name	(2S)-6-amino-2-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid,hydrochloride
Synonyms	Nalpha-Fmoc-L-lysinehydrochloride (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-6-aminohexanoic acid hydrochloride Fmoc-Lys-OH hydrochloride Nα-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine Hydrochloride Fmoc-Lys-OH.HCl Fmoc-L-lysine HCl N2-Fmoc-L-lysine HCl MFCD00190889 Fmoc-L-lysine hydrochloride Nalpha-Fmoc-L-Lysine Hydrochloride L-Lysine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, hydrochloride (1:1) Nalpha-[(9H-Fluoren-9-ylMethoxy)carbonyl]-L-lysine Hydrochloride Fmoc-Lys-OH inverted exclamation mark currencyHCl N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine hydrochloride (1:1) Nα-Fmoc-L-lysine Hydrochloride

Description	Fmoc-Lys-OH hydrochloride is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Lys-OH hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2924299090

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%