Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Myosmine
Price: ￥2078.0/50mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Myosmine
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

532-12-7

532-12-7 structure

532-12-7 structure

Name: Myosmine
Chemical Name: 3-(3,4-dihydro-2H-pyrrol-5-yl)pyridine
CAS Number: 532-12-7
Molecular Formula: C₉H₁₀N₂
Molecular Weight: 146.189
Catalog: Natural product Alkaloid
Create Date: 2018-03-30 08:00:00
Modify Date: 2024-01-01 22:34:52
Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a Ki of 3300 nM[1][2].

Name	3-(3,4-dihydro-2H-pyrrol-5-yl)pyridine
Synonyms	Prestwick_202 3-(4,5-dihydro-3H-pyrrol-2-yl)-pyridine Pyridine, 3-(1-pyrrolin-2-yl)- dehydronornicotine 3-(3,4-Dihydro-2H-pyrrol-5-yl)pyridine Pyridine, 3-(3,4-dihydro-2H-pyrrol-5-yl)- MFCD00052019 3-(1-Pyrrolin-2-yl)pyridine Myosmine Pyridine,3-(3,4-dihydro-2H-pyrrol-5-yl)

Description	Myosmine, a specific tobacco alkaloid in nuts and nut products, has low affinity for a4b2 nicotinic acetylcholinergic receptors (nAChR) with a Ki of 3300 nM[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Metabolic Disease
Target	Ki: 3300 nM (a4b2 nAChR) and >10 µM (AT1)[1]
In Vitro	Myosmine is easily nitrosated, yielding 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and the esophageal tobacco carcinogen N'-nitrosonornicotine[2].
In Vivo	Myosmine (0.001, 0.005, 0.5, and 50 micromol/kg; oral; in Wistar rats) causes a higher percentage of the radioactivity excreted in urine (86.2% and 88.9%) at the two lower doses (0.001 and 0.005 micromol/kg),as compared with the higher doses (0.5 and 50 micromol/kg), where only 77.8% and 75.4% of the dose is found in urine[2].
References	[1]. G Ferretti, er al. Binding of Nicotine and Homoazanicotine Analogues at Neuronal Nicotinic Acetylcholinergic (nACh) Receptors. Bioorg Med Chem Lett. 2003 Feb 24;13(4):733-5. [2]. Wolfgang Zwickenpflug, et al. Metabolism of Myosmine in Wistar Rats. Drug Metab Dispos. 2005 Nov;33(11):1648-56.

Density	1.1±0.1 g/cm3
Boiling Point	244.7±22.0 °C at 760 mmHg
Melting Point	42-44°C
Molecular Formula	C₉H₁₀N₂
Molecular Weight	146.189
Flash Point	101.8±22.3 °C
Exact Mass	146.084396
PSA	25.25000
LogP	-0.63
Vapour Pressure	0.0±0.5 mmHg at 25°C
Index of Refraction	1.611
Storage condition	2-8°C
Stability	Moisture, Temperature Sensitive

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UT7660000

CHEMICAL NAME :: Pyridine, 3-(1-pyrrolin-2-yl)-

CAS REGISTRY NUMBER :: 532-12-7

BEILSTEIN REFERENCE NO. :: 0119254

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H10-N2

MOLECULAR WEIGHT :: 146.21

WISWESSER LINE NOTATION :: T6NJ C- BT5N AUTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1875 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 63,423,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 190 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04- Volume(issue)/page/year: 63,423,1946

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn
Risk Phrases	R22
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	UT7660000
HS Code	2933990090

Precursor 8
93-60-7 36740-10-0 123-75-1 1120-90-7
22083-74-5 88-12-0 614-18-6 87549-96-0
DownStream 8
59578-62-0 80508-23-2 5746-86-1 1772-29-8
22083-74-5 54-11-5 25162-00-9 6021-23-4

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%