107008-28-6

107008-28-6 structure

Name: RU 24969 hemisuccinate
Chemical Name: RU 24969 hemisuccinate
CAS Number: 107008-28-6
Molecular Formula: C₃₂H₃₈N₄O₆
Molecular Weight: 574.667
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-11-21 13:02:16
Modify Date: 2024-01-09 20:27:54
RU 24969 succinate is a 5-HT receptor agonist with Ki values of 0.38 and 2.5 nM for 5-HT1B and 5-HT1A, respectively. RU 24969 decreases fluid consumption and increases forward locomotion. RU 24969 succinate can be used for the research of neurological disease[1][2][3][4].

Name	RU 24969 hemisuccinate
Synonyms	5-Methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole succinate (2:1) 5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole succinate 1H-Indole, 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-, butanedioate (2:1) Succinic acid - 5-methoxy-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1H-indole (1:2) 5-METHOXY-3-(1,2,5,6-TETRAHYDRO-4-PYRIDINYL)-1H-INDOLE HEMISUCCINATE

Description	RU 24969 succinate is a 5-HT receptor agonist with Ki values of 0.38 and 2.5 nM for 5-HT1B and 5-HT1A, respectively. RU 24969 decreases fluid consumption and increases forward locomotion. RU 24969 succinate can be used for the research of neurological disease[1][2][3][4].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Target	Ki: 0.38 nM (5-HT1B), 2.5 nM (5-HT1A)[3]
In Vitro	RU 24969 succinate (30 nM-1 μM) 抑制 K+ 诱发的氚外排，在 1 μM 浓度下 pD2 为 7.45[1]。
In Vivo	RU 24969 succinate (1 和 3 mg/kg；皮下注射，1 次) 增强可卡因诱导产生的作用[2]。 RU 24969 succinate (0.03-3.0 mg/kg；皮下注射，1 次) 剂量依赖性地减少水剥夺大鼠的水消耗[4]。 Animal Model: Male Wistar rats with cocaine injection[2] Dosage: 1 and 3 mg/kg Administration: Subcutaneous injection; 1 and 3 mg/kg, once Result: Increased cocaine-induced elevation of nucleus accumbens (NAcc) dopamine DA levels and reduction of ventral tegmental area (VTA) GABA levels.
References	[1]. Middlemiss DN. The putative 5-HT1 receptor agonist, RU 24969, inhibits the efflux of 5-hydroxytryptamine from rat frontal cortex slices by stimulation of the 5-HT autoreceptor. J Pharm Pharmacol. 1985 Jun;37(6):434-7. [2]. Parsons LH, et al. RU 24969, a 5-HT1B/1A receptor agonist, potentiates cocaine-induced increases in nucleus accumbens dopamine. Synapse. 1999 May;32(2):132-5. [3]. Peroutka SJ. Pharmacological differentiation and characterization of 5-HT1A, 5-HT1B, and 5-HT1C binding sites in rat frontal cortex. J Neurochem. 1986 Aug;47(2):529-40. [4]. Aronsen D, et al. RU 24969-produced adipsia and hyperlocomotion: differential role of 5HT 1A and 5HT 1B receptor mechanisms. Pharmacol Biochem Behav. 2014 Sep;124:1-4.

Boiling Point	434.6ºC at 760mmHg
Molecular Formula	C₃₂H₃₈N₄O₆
Molecular Weight	574.667
Flash Point	216.7ºC
Exact Mass	574.279114
PSA	148.70000
LogP	5.69980

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