85753-43-1

85753-43-1 structure

Name: K252C
Chemical Name: K-252c,6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
CAS Number: 85753-43-1
Molecular Formula: C₂₀H₁₃N₃O
Molecular Weight: 311.33700
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2016-06-27 07:08:04
Modify Date: 2024-01-11 12:32:37
K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase[1][2][3].

Name	K-252c,6,7,12,13-Tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
Synonyms	staurosporine aglycon Staurosporinone,K-252c Staurosporinone K-252C STAUROSPORINE AGLYCONE

Description	K-252c, a staurosporine analog isolated from Nocardiopsis sp., is a cell-permeable PKC inhibitor, with an IC50 of 2.45 µM. K-252c induces apoptosis in human chronic myelogenous leukemia cancer cells. K-252c also inhibits β-lactamase, chymotrypsin, and malate dehydrogenase[1][2][3].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> TGF-beta/Smad >> PKC Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 2.45 µM (PKC)[1].
References	[1]. Pereira, E.R., et al. Structure-activity relationships in a series of substituted indolocarbazoles: Topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties J. Med. Chem. 39(22), 4471-4477 (1996). [2]. Liu, R., et al. Two indolocarbazole alkaloids with apoptosis activity from a marine-derived actinomycete Z2039-2 Arch. Pharm. Res. 30(3), 270-274 (2007). [3]. Zimmermann, A., et al. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase Antiviral Res. 48(1), 49-60 (2000). [4]. McGovern, S.L., et al. Kinase inhibitors: Not just for kinases anymore Journal of Medicinal Chemistry 46, 1478-1483 (2003).

Precursor 3
118458-54-1 51925-58-7 40899-99-8
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%