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122-60-1

122-60-1 structure
122-60-1 structure

Name Glycidyl phenyl ether
Synonyms 2-(Phenoxymethyl)oxirane
2,3-Epoxy-1-phenoxypropane
glycidol phenyl ether
phenol glycidyl ether
Oxirane, (phenoxymethyl)-
1,2-epoxy-3phenoxy propane
UNII-44KJQ1655I
benzene, (2,3-epoxypropoxy)-
Ether, 2,3-epoxypropyl phenyl
Phenyl 2,3-epoxypropyl ether
3-Phenoxy-1,2-propylene oxide
3-Phenyloxy-1,2-epoxypropane
EINECS 204-557-2
MFCD00005133
1-Phenoxy-2,3-epoxypropane
1,2-Epoxy-3-phenoxypropane
phenoxypropene oxide
Oxirane, 2-(phenoxymethyl)-
Glycidyl phenyl ether
2,3-Epoxypropyl phenyl ether
3-phenoxy-1,2-epoxypropane
phenylglycidyl ether
propane, 1,2-epoxy-3-phenoxy-
Density 1.1±0.1 g/cm3
Boiling Point 245.0±0.0 °C at 760 mmHg
Melting Point 3.5 °C(lit.)
Molecular Formula C9H10O2
Molecular Weight 150.174
Flash Point 94.8±19.4 °C
Exact Mass 150.068085
PSA 21.76000
LogP 1.74
Vapour density 5.2 (vs air)
Vapour Pressure 0.0±0.4 mmHg at 25°C
Index of Refraction 1.537
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility 2.4 g/L (20 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TZ3675000
CHEMICAL NAME :
Propane, 1,2-epoxy-3-phenoxy-
CAS REGISTRY NUMBER :
122-60-1
BEILSTEIN REFERENCE NO. :
0002744
LAST UPDATED :
199712
DATA ITEMS CITED :
56
MOLECULAR FORMULA :
C9-H10-O2
MOLECULAR WEIGHT :
150.19
WISWESSER LINE NOTATION :
T3OTJ B1OR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3850 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Behavioral - ataxia
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>100 ppm/8H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1400 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity) Behavioral - ataxia
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>100 ppm/4H
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - acute pulmonary edema
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
760 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
1500 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 ppm/6H/90D-I
TOXIC EFFECTS :
Skin and Appendages - hair
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
12 ppm/6H/2Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Olfaction) - tumors
TYPE OF TEST :
TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE :
Inhalation
DOSE :
11 ppm/6H
SEX/DURATION :
male 19 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Lung
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 249,55,1991 *** REVIEWS *** ACGIH TLV-Animal carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 0.6 mg/m3 (0.1 ppm) (skin) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 47,237,1989 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 47,237,1989 TOXICOLOGY REVIEW AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 113,130,1972 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 10 ppm (62 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,206,1971 OSHA PEL (Gen Indu):8H TWA 10 ppm (60 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 10 ppm (60 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 10 ppm (60 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 10 ppm (60 mg/m3) CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 1 ppm (6 mg/m3) JAN 1993 OEL-BELGIUM:TWA 1 ppm (6.1 mg/m3) JAN 1993 OEL-DENMARK:TWA 1 ppm (5 mg/m3) JAN 1993 OEL-FINLAND:STEL 10 ppm (60 mg/m3);Skin JAN 1993 OEL-FRANCE:TWA 1 ppm (6 mg/m3) JAN 1993 OEL-GERMANY:TWA 1 ppm (6 mg/m3);Carcinogen JAN 1993 OEL-THE NETHERLANDS:TWA 1 ppm (6 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 10 ppm (62 mg/m3) JAN 1993 OEL-SWEDEN:TWA 10 ppm (60 mg/m3);STEL 15 ppm (90 mg/m3) JAN 1993 OEL-SWITZERLAND:TWA 1 ppm (6 mg/m3);STEL 2 ppm (12 mg/m3) JAN 1993 OEL-TURKEY:TWA 10 ppm (60 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 1 ppm (6 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO PHENYL GLYCIDYL ETHER-air:CA CL 1 ppm/15M REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 57280 No. of Facilities: 434 (estimated) No. of Industries: 13 No. of Occupations: 12 No. of Employees: 8533 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 57280 No. of Facilities: 355 (estimated) No. of Industries: 15 No. of Occupations: 18 No. of Employees: 10551 (estimated) No. of Female Employees: 4108 (estimated)
Symbol GHS05 GHS07 GHS08
GHS05, GHS07, GHS08
Signal Word Danger
Hazard Statements H312 + H332-H315-H317-H318-H335-H341-H350-H412
Precautionary Statements P201-P261-P273-P280-P305 + P351 + P338-P308 + P313
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes T:Toxic;
Risk Phrases R20;R37/38;R43;R45;R52/53;R68
Safety Phrases S53-S45-S61
RIDADR 1760.0
WGK Germany 3
RTECS TZ3675000
HS Code 29109000
HS Code 2910900090
Summary 2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%