DC Chemicals Limited
China
Product Name: Ivermectin B1b
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Avermectin A1a, 5-O-demethyl-25-de(1-methylpropyl)-22,23-dihydro-25-(1-methylethyl)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

70209-81-3

70209-81-3 structure

70209-81-3 structure

Name: Dihydroavermectin B1b
Chemical Name: 22,23-dihydroavermectin B1b
CAS Number: 70209-81-3
Molecular Formula: C₄₇H₇₂O₁₄
Molecular Weight: 861.06600
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2016-04-03 00:40:14
Modify Date: 2024-01-12 16:30:29
Ivermectin B1b is the minor component of Ivermectin. Ivermectin, a potent anti-parasitic agent, inhibits the replication of SARS-CoV-2 in cell culture[1][2].

Name	22,23-dihydroavermectin B1b
Synonyms	ivermectin B1b IVERMECTIN B1B (DIHYDROAVERMECTIN B1B, 22, 23-DIHYDROAVERMECTIN B1B ) DIHYDROAVERMECTIN B1B

Description	Ivermectin B1b is the minor component of Ivermectin. Ivermectin, a potent anti-parasitic agent, inhibits the replication of SARS-CoV-2 in cell culture[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
In Vitro	Ivermectin and Ivermectin B1b are the most potent inhibitors of contraction and motility in both susceptible isolates (H. contortus McMaster and and O. circumcincta McMaster) also show the highest resistance ratios in both species[3]. Vermectin is a macrocyclic lactone that acts as a positive allosteric modulator of α7 nicotinic acetylcholine receptors (nAChRs) but has no modulatory activity on 5-HT3 receptors[4].
In Vivo	Ivermectin B1b causes snail death[1].
References	[1]. Katz N, et al. Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis. J Antibiot (Tokyo). 2017;70(5):680-684. [2]. Bray M, et al. Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses. Antiviral Res. 2020;178:104805. [3]. Demeler J, et al. Measuring the effect of avermectins and milbemycins on somatic muscle contraction of adult Haemonchus contortus and on motility of Ostertagia circumcincta in vitro. Parasitology. 2014;141(7):948-956. [4]. Collins T, et al. Nicotinic acetylcholine receptor transmembrane mutations convert ivermectin from a positive to a negative allosteric modulator. Mol Pharmacol. 2010;78(2):198-204.

Molecular Formula	C₄₇H₇₂O₁₄
Molecular Weight	861.06600
Exact Mass	860.49200
PSA	170.06000
LogP	5.21130

RIDADR	UN 2588