72583-92-7
72583-92-7 structure
- Name: 1H-Imidazole, 2-(2-benzofuranyl)-4,5-dihydro-
- Chemical Name: 2-(1-benzofuran-2-yl)-4,5-dihydro-1H-imidazole
- CAS Number: 72583-92-7
- Molecular Formula: C11H10N2O
- Molecular Weight: 186.21
- Catalog: Signaling Pathways GPCR/G Protein Imidazoline Receptor
- Create Date: 2018-12-02 19:38:59
- Modify Date: 2024-01-03 22:23:56
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RX 801077 (2 BFI free base) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 shows anti-inflammation and neuroprotection. RX 801077 has the potential for the research of traumatic brain injury (TBI)[1][2].
| Name | 2-(1-benzofuran-2-yl)-4,5-dihydro-1H-imidazole |
|---|---|
| Synonyms |
2-(2-Benzofuranyl)-2-imidazoline
2-benzofuran-2-yl-4,5-dihydro-1H-imidazole 2xcg 2-BFi (3H)2-Bfi 3H-2-(2-benzofuranyl)-2-imidazoline Tocris-0348 2-(2'-Imidazolinyl)benzofuran |
| Description | RX 801077 (2 BFI free base) is a selective imidazoline I2 receptor (I2R) agonist with a Ki value of 70.1 nM. RX 801077 shows anti-inflammation and neuroprotection. RX 801077 has the potential for the research of traumatic brain injury (TBI)[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Ki: 70.1 nM (imidazoline I2 receptor)[2] |
| In Vivo | RX 801077 (5、10、20 mg/kg；腹腔注射；每天两次，持续 3 天) 在创伤性脑损伤大鼠模型中抑制 NLRP3 炎性体诱导的炎症和坏死性凋亡[2]。 Animal Model: 280-300 g, Male adult Sprague-Dawley rats (TBI model)[2] Dosage: 5, 10, 20 mg/kg Administration: I.p.; twice daily for 3 days Result: Attenuated neurological deficits, brain edema, BBB permeability and cortical tissue loss in a rat model of TBI, reduced microglial activation, neutrophil infiltration, and proinflammatory cytokine IL-1β secretion, reduced the expression of RIP1 and RIP3 in neurons in the pericontusional cortex. |
| References |
| Molecular Formula | C11H10N2O |
|---|---|
| Molecular Weight | 186.21 |
| Exact Mass | 186.07900 |
| PSA | 37.53000 |
| LogP | 1.54700 |
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72583-92-7 |
| Literature: Sant' Anna, Gabriela da S.; Machado, Pablo; Sauzem, Patricia D.; Rosa, Fernanda A.; Rubin, Maribel A.; Ferreira, Juliano; Bonacorso, Helio G.; Zanatta, Nilo; Martins, Marcos A.P. Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 2 p. 546 - 549 |
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72583-92-7 |
| Literature: Anastassiadou; Baziard-Mouysset; Payard Synthesis, 2000 , # 13 p. 1814 - 1816 |
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72583-92-7 |
| Literature: Shridhar,D.R. et al. Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1979 , vol. 18, p. 254 - 256 |
| Precursor 4 | |
|---|---|
| DownStream 0 | |