4213-45-0

4213-45-0 structure

Name: Quinacrine mustard dihydrochloride
Chemical Name: quinacrine mustard dihydrochloride
CAS Number: 4213-45-0
Molecular Formula: C₂₃H₃₀Cl₅N₃O
Molecular Weight: 541.76900
Catalog: Research Areas Others
Create Date: 2018-08-02 20:09:00
Modify Date: 2024-01-05 10:08:33
Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent can be used as mutagenic agent induces the mutants of bacteria. Quinacrine mustard dihydrochloride induces cell cycle arrest at G2/M-phase. Quinacrine mustard dihydrochloride has the potential for the research of plant, animal, or human chromosomes[1][2][3].

Name	quinacrine mustard dihydrochloride
Synonyms	Quinacrine mustard dihydrochloride N4,N4-Bis-(2-chlor-aethyl)-N1-(6-chlor-2-methoxy-acridin-9-yl)-1-methyl-butandiyldiamin,Dihydrochlorid N1,N1-bis(2-chloroethyl)-N4-(6-chloro-2-methoxyacridin-9-yl)pentane-1,4-diamine dihydrochloride EINECS 224-140-9 N4,N4-bis-(2-chloro-ethyl)-N1-(6-chloro-2-methoxy-acridin-9-yl)-1-methyl-butanediyldiamine,dihydrochloride quinacrine mustard Atabrine mustard dihydrochloride ICR 10 3-chloro-7-methoxy-9-(1-methyl-4-(N,N-bis(2-chloroethyl)amino)butylamino)acridine dihydrochloride 1-N,1-N-bis(2-chloroethyl)-4-N-(6-chloro-2-methoxyacridin-9-yl)pentane-1,4-diamine,dihydrochloride Mepacrine mustard dihydrochloride

Description	Quinacrine mustard dihydrochloride is a fluorochrome. Quinacrine mustard dihydrochloride as a polycyclic aromatic agent can be used as mutagenic agent induces the mutants of bacteria. Quinacrine mustard dihydrochloride induces cell cycle arrest at G2/M-phase. Quinacrine mustard dihydrochloride has the potential for the research of plant, animal, or human chromosomes[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	Quinacrine mustard dihydrochloride (5 µg/ml) can be used for the DNA strain of plant, animal, or human chromosomes[1]. Quinacrine mustard dihydrochloride (28 µM) increases the number ofmutants that appeared after an exposure of bacteria[2]. quinacrine mustard dihydrochloride (0.2 µM; 4h) induces cell cycle arrest at G2+M-phase in HL-60 cells[3]. Caffeine (5 mM) prevents the cytotoxic action of quinacrine mustard dihydrochloride (0.2 µM; 4h) in HL-60 cells[3]. Cell Cycle Analysis[3] Cell Line: HL-60 cells Concentration: 0.2 µM Incubation Time: 4 h Result: Induced cell cycle arrest at G2+M-phase with the accumulation of cells in this compartment by 50%.
References	[1]. Caspersson T, et al. Fluorescent labeling of chromosomal DNA: superiority of quinacrine mustard to quinacrine. Science. 1970 Nov 13;170(3959):762. [2]. Piosik J, et al. Alleviation of mutagenic effects of polycyclic aromatic agents (quinacrine mustard, ICR-191 and ICR-170) by caffeine and pentoxifylline. Mutat Res. 2003 Sep 29;530(1-2):47-57. [3]. Kapuscinski J, et al. The modulation of the DNA-damaging effect of polycyclic aromatic agents by xanthines. Part I. Reduction of cytostatic effects of quinacrine mustard by caffeine. Biochem Pharmacol. 2002 Feb 15;63(4):625-34.

Density	1.271g/cm3
Boiling Point	574.1ºC at 760 mmHg
Melting Point	150 °C
Molecular Formula	C₂₃H₃₀Cl₅N₃O
Molecular Weight	541.76900
Flash Point	301ºC
Exact Mass	539.08300
PSA	37.39000
LogP	8.08720
Index of Refraction	1.632

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR7580000

CHEMICAL NAME :: Acridine, 9-(4-bis(2-chloroethyl)amino-1-methylbutylamino)-6-ch loro-2-methoxy-, dihydrochloride

CAS REGISTRY NUMBER :: 4213-45-0

LAST UPDATED :: 199710

DATA ITEMS CITED :: 15

MOLECULAR FORMULA :: C23-H28-Cl3-N3-O.2Cl-H

MOLECULAR WEIGHT :: 541.81

WISWESSER LINE NOTATION :: T C666 BNJ EG IMY3N2G2G LO1 &GH &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2700 ug/kg

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

TYPE OF TEST :: Specific locus test

TYPE OF TEST :: Sex chromosome loss and nondisjunction

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 50 umol/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 26,553,1974

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301-H317-H331-H334-H361
Precautionary Statements	P261-P280-P301 + P310-P311
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+
Risk Phrases	46-23/25-42/43
RIDADR	UN 3249
RTECS	AR7580000
Packaging Group	III
Hazard Class	6.1(b)

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