352534-95-3

352534-95-3 structure

Name: PIPES-d18
Chemical Name: piperazine-n,n'-bis(2-ethanesulfonic acid)-d18
CAS Number: 352534-95-3
Molecular Formula: C₈D₁₈N₂O₆S₂
Molecular Weight: 320.47900
Catalog: Signaling Pathways Others Others
Create Date: 2018-12-31 22:25:32
Modify Date: 2024-01-14 13:07:04
PIPES-d18 is the deuterium labeled PIPES[1]. PIPES (1,4-Piperazinediethanesulfonic acid) is an important component of PIPES buffer agent used in biochemistry[2].

Name	piperazine-n,n'-bis(2-ethanesulfonic acid)-d18

Description	PIPES-d18 is the deuterium labeled PIPES[1]. PIPES (1,4-Piperazinediethanesulfonic acid) is an important component of PIPES buffer agent used in biochemistry[2].
Related Catalog	Signaling Pathways >> Others >> Others
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Jason Moggridge, et al. Sensitive Detection of Immunoglobulin G Stability Using in Real-Time Isothermal Differential Scanning Fluorimetry: Determinants of Protein Stability for Antibody-Based Therapeutics. Technol Cancer Res Treat. 2017 Dec;16(6):997-1005.