89889-51-0

89889-51-0 structure

Name: Biotin-C5-amino-C5-amino
Chemical Name: 6-[6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoylamino]hexanoic acid
CAS Number: 89889-51-0
Molecular Formula: C₂₂H₃₈N₄O₅S
Molecular Weight: 470.62600
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-03-22 00:56:19
Modify Date: 2024-01-04 20:19:34
Biotin-C5-amino-C5-amino is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	6-[6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoylamino]hexanoic acid
Synonyms	D-biotinylaminohexanoylaminohexanoic acid D-biotin-Acp-Acp-OH N-Biotinylcaproylaminocaproic Acid

Description	Biotin-C5-amino-C5-amino is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl-Chain
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₂₂H₃₈N₄O₅S
Molecular Weight	470.62600
Exact Mass	470.25600
PSA	172.40000
LogP	3.79940
Storage condition	2-8°C

72040-64-3

60-32-2

89889-51-0

Literature: Plaziuk, Damian; Zakrzewski, Janusz; Salmain, Michele; Blauzi, Andrzej; Rychlik, Blaziej; Strzelczyk, Pawel; Bujacz, Anna; Bujacz, Grzegorz Organometallics, 2013 , vol. 32, # 20 p. 5774 - 5783

Precursor 2
72040-64-3 60-32-2
DownStream 0

89889-51-0	72040-63-2
1260586-88-6	129480-26-8
916165-67-8	146385-37-7
2241685-22-1	1260247-50-4
151294-96-1	154024-76-7