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300762-25-8

300762-25-8 structure
300762-25-8 structure
  • Name: Hydrocarbon chain derivative 1
  • Chemical Name: 6-(6-hydroxy-5,5-dimethylhexoxy)-2,2-dimethylhexan-1-ol
  • CAS Number: 300762-25-8
  • Molecular Formula: C16H34O3
  • Molecular Weight: 274.43900
  • Catalog: Research Areas Metabolic Disease
  • Create Date: 2016-08-16 00:12:44
  • Modify Date: 2024-01-08 13:42:19
  • Hydrocarbon chain derivative 1 is an active compound, with inhibitory activities against lipid synthesis.
Name 6-(6-hydroxy-5,5-dimethylhexoxy)-2,2-dimethylhexan-1-ol
Synonyms Hydrocarbon chain derivative 1
Description Hydrocarbon chain derivative 1 is an active compound, with inhibitory activities against lipid synthesis.
Related Catalog
In Vivo Hydrocarbon chain derivative 1 is well tolerated with mild liver effects at 2000 mg/kg in rats[1]. Hydrocarbon chain derivative 1 shows inhibitory effect on lipid synthesis, with an IC50 of 11 μM[2].
References

[1]. Oniciu DC, et al. Influence of various central moieties on the hypolipidemic properties of long hydrocarbon chain diols and diacids. J Med Chem. 2006 Jan 12;49(1):334-48.

[2]. Oniciu DC, et al. Long hydrocarbon chain diols and diacids with central ether or ketone moieties that favorably alter lipid disorders. Pharmazie. 2006 Feb;61(2):157-65.
Molecular Formula C16H34O3
Molecular Weight 274.43900
Exact Mass 274.25100
PSA 49.69000
LogP 3.38060
615288-01-2 structure

615288-01-2

~%

300762-25-8 structure

300762-25-8
Literature: Dasseux, Jean-Louis Henri; Oniciu, Carmen Daniela Patent: US2004/192771 A1, 2004 ;
163163-99-3 structure

163163-99-3

~%

300762-25-8 structure

300762-25-8
Literature: Mueller, Ralf; Yang, Jing; Duan, Caiming; Pop, Emil; Lian, Hao Zhang; Huang, Tian-Bao; Denisenko, Anna; Denisko, Olga V.; Oniciu, Daniela C.; Bisgaier, Charles L.; Pape, Michael E.; Freiman, Catherine Delaney; Goetz, Brian; Cramer, Clay T.; Hopson, Krista L.; Dasseux, Jean-Louis H. Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5183 - 5197
163163-99-3 structure

163163-99-3
300762-16-7 structure

300762-16-7

~%

300762-25-8 structure

300762-25-8
Literature: ESPERION THERAPEUTICS, INC. Patent: WO2005/68410 A1, 2005 ; Location in patent: Page/Page column 261; 268-269 ; WO 2005/068410 A1
300762-16-7 structure

300762-16-7

~%

300762-25-8 structure

300762-25-8
Literature: Mueller, Ralf; Yang, Jing; Duan, Caiming; Pop, Emil; Lian, Hao Zhang; Huang, Tian-Bao; Denisenko, Anna; Denisko, Olga V.; Oniciu, Daniela C.; Bisgaier, Charles L.; Pape, Michael E.; Freiman, Catherine Delaney; Goetz, Brian; Cramer, Clay T.; Hopson, Krista L.; Dasseux, Jean-Louis H. Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5183 - 5197
Precursor  1

DownStream  0


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