1093070-16-6

1093070-16-6 structure

Name: GRL 0617
Chemical Name: 5-amino-2-methyl-N-(2-naphthalen-1-ylethyl)benzamide
CAS Number: 1093070-16-6
Molecular Formula: C₂₀H₂₀N₂O
Molecular Weight: 304.38600
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2018-12-03 11:22:25
Modify Date: 2024-01-06 11:07:51
GRL0617 is a potent, selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLpro)/deubiquitinase, with an IC50 of 0.6 μM, and with a Ki of 0.49 μM[1].

Name	5-amino-2-methyl-N-(2-naphthalen-1-ylethyl)benzamide
Synonyms	I06-1403 5-azanyl-2-methyl-N-(2-naphthalen-1-ylethyl)benzamide 5-amino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide 5-amino-2-methyl-N-[2-(1-naphthalenyl)ethyl]benzamide

Description	GRL0617 is a potent, selective and competitive noncovalent inhibitor of severe acute respiratory syndrome (SARS-CoV) papain-like protease (PLpro)/deubiquitinase, with an IC50 of 0.6 μM, and with a Ki of 0.49 μM[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> Deubiquitinase Signaling Pathways >> Anti-infection >> SARS-CoV
Target	IC50: 0.6 μM (SARS-CoV PLpro)[1]
References	[1]. Ratia K, et al. A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24.