CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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MA5599000
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CHEMICAL NAME :
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Glutaronitrile, 2-bromo-2-(bromomethyl)-
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CAS REGISTRY NUMBER :
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35691-65-7
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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13
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MOLECULAR FORMULA :
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C6-H6-Br2-N2
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MOLECULAR WEIGHT :
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265.96
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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REFERENCE :
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JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 15,140,1996
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TYPE OF TEST :
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Standard Draize test
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ROUTE OF EXPOSURE :
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Administration into the eye
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SPECIES OBSERVED :
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Rodent - rabbit
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REFERENCE :
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JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 15,140,1996 ** ACUTE TOXICITY DATA **
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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515 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 15,140,1996
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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>13 gm/m3/4H
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 15,140,1996
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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>5 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 15,140,1996 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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84 gm/kg/3W-I
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TOXIC EFFECTS :
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Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count Skin and Appendages - dermatitis, other (after systemic exposure)
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REFERENCE :
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JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 15,140,1996
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Mammal - dog
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DOSE/DURATION :
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380 mg/kg/13W-C
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TOXIC EFFECTS :
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Endocrine - changes in thyroid weight
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REFERENCE :
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JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 15,140,1996
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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120 mg/kg/4W-I
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TOXIC EFFECTS :
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Blood - pigmented or nucleated red blood cells
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REFERENCE :
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JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued. Volume(issue)/page/year: 15,140,1996 ** REPRODUCTIVE DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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DOSE :
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1750 mg/kg
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SEX/DURATION :
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female 6-15 day(s) after conception
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TOXIC EFFECTS :
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Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
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REFERENCE :
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TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- Volume(issue)/page/year: 18(Suppl 1),158,1983 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1017 No. of Facilities: 512 (estimated) No. of Industries: 9 No. of Occupations: 10 No. of Employees: 17713 (estimated) No. of Female Employees: 3345 (estimated)
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