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17557-67-4

17557-67-4 structure
17557-67-4 structure
  • Name: 6-(Methylsulfonyl)-1,3-benzothiazol-2-amine
  • Chemical Name: 2-Amino-6-(Methylsulfonyl)Benzothiazole
  • CAS Number: 17557-67-4
  • Molecular Formula: C8H8N2O2S2
  • Molecular Weight: 228.29
  • Catalog: Research Areas Infection
  • Create Date: 2018-09-29 19:00:35
  • Modify Date: 2024-01-02 19:53:08
  • TbPTR1 inhibitor 2 (Compound 3a) is a PTR1 enzyme inhibitor, with IC50s of 34.2 and 32.9 μM for TbPTR1 and LmPTR1. TbPTR1 inhibitor 2 has anti-parasitic activity against T. brucei (IC50: 34.2 μM)[1].
Name 2-Amino-6-(Methylsulfonyl)Benzothiazole
Synonyms 2-amino-6-(methylsulfonyl)benzothiazole
6-(Methylsulfonyl)-1,3-benzothiazol-2-amine
MFCD00179133
2-Amino-6-methylsulfonylbenzothiazole
6-methylsulfonyl-1,3-benzothiazol-2-amine
2-Benzothiazolamine, 6-(methylsulfonyl)-
EINECS 241-537-2
Description TbPTR1 inhibitor 2 (Compound 3a) is a PTR1 enzyme inhibitor, with IC50s of 34.2 and 32.9 μM for TbPTR1 and LmPTR1. TbPTR1 inhibitor 2 has anti-parasitic activity against T. brucei (IC50: 34.2 μM)[1].
Related Catalog
References

[1]. Linciano P, et al. Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections. J Med Chem. 2019 Apr 25;62(8):3989-4012.  

Density 1.5±0.1 g/cm3
Boiling Point 500.8±56.0 °C at 760 mmHg
Melting Point 223 °C (dec.)(lit.)
Molecular Formula C8H8N2O2S2
Molecular Weight 228.29
Flash Point 256.7±31.8 °C
Exact Mass 228.002716
PSA 109.67000
LogP 0.17
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.688

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DL0863408
CHEMICAL NAME :
2-Benzothiazolamine, 6-(methylsulfonyl)-
CAS REGISTRY NUMBER :
17557-67-4
LAST UPDATED :
199806
DATA ITEMS CITED :
3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534339
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - excitement Behavioral - ataxia
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0534339
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36-S36/37/39-S22
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS DL0863408
HS Code 2934999090
HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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