80-26-2

80-26-2 structure

Name: α-Terpinyl acetate
Chemical Name: Terpinyl Acetate
CAS Number: 80-26-2
Molecular Formula: C₁₂H₂₀O₂
Molecular Weight: 196.286
Catalog: Flavors and spices Synthetic spice Carboxylic acid and ester perfume Aliphatic carboxylate
Create Date: 2018-07-20 17:01:57
Modify Date: 2024-01-03 08:40:50
α-Terpinyl acetate is a monoterpene ester isolated from Laurus nobilis L. essential oil. α-Terpinyl acetate is a competitive P450 2B6 substrate which binding to the active site of P450 2B6 with a Kd value of 5.4 μM[1][2].

Name	Terpinyl Acetate
Synonyms	MFCD00037155 a-terpinyl acetate, (±) (±)-α-Terpineol acetate EINECS 201-265-7 2-(4-Methyl-3-cyclohexen-1-yl)-2-propyl acetate 2-(4-Methyl-3-cyclohexen-1-yl)-2-propanyl acetate p-Menth-1-en-8-ol acetate 3-Cyclohexene-1-methanol, α,α,4-trimethyl-, acetate (±)-2-(4-Methyl-3-cyclohexen-1-yl)-2-propanylacetat 1-Methyl-1-(4-methylcyclohex-3-en-1-yl)ethyl acetate L6UTJ A1 DX1&1&OV1 Terpinyl acetate (±)-a-Terpinyl acetate p-Menth-1-en-8-ol, acetate

Description	α-Terpinyl acetate is a monoterpene ester isolated from Laurus nobilis L. essential oil. α-Terpinyl acetate is a competitive P450 2B6 substrate which binding to the active site of P450 2B6 with a Kd value of 5.4 μM[1][2].
Related Catalog	Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Research Areas >> Metabolic Disease
Target	CYP2B6:5.4  μM (Kd)
In Vitro	The bupropion hydroxylation activity of P450 2B6 is inhibited by α-Terpinyl acetate wiht an IC50 value of 10.4 μM and α-Terpinyl acetate is determined to be a competitive inhibitor of P450 2B6 with a Ki of 7.6  μM[2].
References	[1]. Fidan H, et al. Chemical Composition and Antimicrobial Activity of Laurus nobilis L. Essential Oils from Bulgaria. Molecules. 2019 Feb 22;24(4). [2]. Lee Y, et al. Inhibitory effect of α-terpinyl acetate on cytochrome P450 2B6 enzymatic activity. Chem Biol Interact. 2018 Jun 1;289:90-97.

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity)

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 2,327,1964

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(10),27,1993

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(10),27,1993 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Liver - fatty liver degeneration Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 58(10),27,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2063 No. of Facilities: 4671 (estimated) No. of Industries: 24 No. of Occupations: 23 No. of Employees: 44114 (estimated) No. of Female Employees: 28016 (estimated)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	OT0200000
HS Code	2915390090

HS Code	2915390090
Summary	2915390090. esters of acetic acid. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:5.5%. General tariff:30.0%