175673-57-1
175673-57-1 structure
- Name: (-)-MDL 100907
- Chemical Name: (S)-(2,3-Dimethoxyphenyl){1-[2-(4-fluorophenyl)ethyl]-4-piperidin yl}methanol
- CAS Number: 175673-57-1
- Molecular Formula: C22H28FNO3
- Molecular Weight: 373.46
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2016-05-31 23:09:11
- Modify Date: 2024-01-14 11:27:11
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(S)-Volinanserin is an isform of Volinanserin (HY-14940). Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity.
| Name | (S)-(2,3-Dimethoxyphenyl){1-[2-(4-fluorophenyl)ethyl]-4-piperidin yl}methanol |
|---|---|
| Synonyms |
(S)-(2,3-dimethoxyphenyl)-{1-[2-(4-fluorophenyl)-ethyl]-piperidin-4-yl}-methanol
(R)-(2,3-dimethoxyphenyl)-{1-[2-(4-fluorophenyl)ethyl]piperidin-4-yl}methanol (S)-(+)-Tricyclamoliodid 1-[(3s)-3-cyclohexyl-3-hydroxy-3-phenylpropyl]-1-methylpyrrolidinium iodide |
| Description | (S)-Volinanserin is an isform of Volinanserin (HY-14940). Volinanserin is a potent and selective antagonist of 5-HT2 receptor, with a Ki of 0.36 nM, and shows 300-fold selectivity for 5-HT2 receptor over 5-HT1c, alpha-1 and DA D2 receptors. Volinanserin has antipsychotic activity. |
|---|---|
| Related Catalog | |
| Target |
Ki: 0.36 nM (5-HT2 receptor)[1] |
| References |
| Molecular Formula | C22H28FNO3 |
|---|---|
| Molecular Weight | 373.46 |
| Exact Mass | 373.20500 |
| PSA | 41.93000 |
| LogP | 3.76890 |
| Storage condition | -20°C |
|
~98%
175673-57-1 |
| Literature: Ullrich, Thomas; Rice, Kenner C. Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 10 p. 2427 - 2432 |
|
~%
175673-57-1 |
| Literature: Morris, David J.; Hayes, Aidan M.; Wills, Martin Journal of Organic Chemistry, 2006 , vol. 71, # 18 p. 7035 - 7044 |
|
~%
175673-57-1 |
| Literature: Morris, David J.; Hayes, Aidan M.; Wills, Martin Journal of Organic Chemistry, 2006 , vol. 71, # 18 p. 7035 - 7044 |
|
~%
175673-57-1 |
| Literature: Morris, David J.; Hayes, Aidan M.; Wills, Martin Journal of Organic Chemistry, 2006 , vol. 71, # 18 p. 7035 - 7044 |
|
~%
175673-57-1 |
| Literature: Morris, David J.; Hayes, Aidan M.; Wills, Martin Journal of Organic Chemistry, 2006 , vol. 71, # 18 p. 7035 - 7044 |
|
~%
175673-57-1 |
| Literature: Ullrich, Thomas; Rice, Kenner C. Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 10 p. 2427 - 2432 |
|
~%
175673-57-1 |
| Literature: Huang, Yiyun; Mahmood, Khalid; Mathis, Chester A. Journal of Labelled Compounds and Radiopharmaceuticals, 1999 , vol. 42, # 10 p. 949 - 957 |
| Precursor 6 | |
|---|---|
| DownStream 1 | |