330981-72-1
330981-72-1 structure
- Name: AS 1269574
- Chemical Name: 2-[[2-(4-bromophenyl)-6-methylpyrimidin-4-yl]amino]ethanol
- CAS Number: 330981-72-1
- Molecular Formula: C13H14BrN3O
- Molecular Weight: 308.174
- Catalog: Signaling Pathways GPCR/G Protein GPR119
- Create Date: 2017-02-11 00:44:53
- Modify Date: 2024-01-12 18:55:15
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AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes[1][2].
| Name | 2-[[2-(4-bromophenyl)-6-methylpyrimidin-4-yl]amino]ethanol |
|---|---|
| Synonyms |
hms1581i01
Ethanol, 2-[[2-(4-bromophenyl)-6-methyl-4-pyrimidinyl]amino]- 2-{[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino}ethanol AS-1269574 |
| Description | AS1269574 is a potent, orally available GPR119 agonist, with an EC50 of 2.5 μM in HEK293 cells expressing human GPR119. AS1269574 activates TRPA1 cation channels to stimulate glucagon-like peptide-1 (GLP-1) secretion. AS1269574 specifically induces glucose-dependent insulin secretion from pancreatic β-cells only under high-glucose conditions. AS1269574 has the potential for the research of type 2 diabetes[1][2]. |
|---|---|
| Related Catalog | |
| Target |
TRPA1 GPR119 |
| In Vivo | AS1269574 sgnificantly reduced the blood glucose AUC after 2 h (AUC0-2h) of administration[1]. Animal Model: Eight-week-old ICR mice[1] Dosage: 100 mg/kg Administration: P.o. Result: Sgnificantly reduced the blood glucose AUC after 2 h (AUC0-2h) of administration. Similarly, plasma insulin AUC0-2h was significantly higher in the mice. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 386.9±42.0 °C at 760 mmHg |
| Molecular Formula | C13H14BrN3O |
| Molecular Weight | 308.174 |
| Flash Point | 187.8±27.9 °C |
| Exact Mass | 307.032013 |
| PSA | 58.04000 |
| LogP | 2.32 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.648 |
| Storage condition | -20℃ |
| Precursor 3 | |
|---|---|
| DownStream 0 | |