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Dayang Chem (Hangzhou) Co., Ltd.
China
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552-94-3

552-94-3 structure

Name: Salsalate
Chemical Name: salsalate
CAS Number: 552-94-3
Molecular Formula: C₁₄H₁₀O₅
Molecular Weight: 258.226
Catalog: API Antipyretic analgesics Antipyretic and analgesic
Create Date: 2018-09-28 10:09:25
Modify Date: 2024-01-08 15:20:41
Salsalate is a nonsteroidal anti-inflammatory drug (NSAID).Target：Salsalate is a medication that belongs to the salicylate and non-steroidal anti-inflammatory drug (NSAID) classes. Relative to other NSAIDs, Salsalate has a weak inhibitory effect on the cyclooxygenase enzyme and decreases the production of several pro inflammatory chemical signals such as interleukin-6, TNF-alpha, and C-reactive protein. Common conditions in which Salsalate may be indicated include inflammatory disorders such as rheumatoid arthritis or noninflammatory disorders such as osteoarthritis.

Name	salsalate
Synonyms	Disalcid EINECS 209-027-4 2-[(2-Hydroxybenzoyl)oxy]benzoic acid Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester 2-(2-hydroxybenzoyl)oxybenzoic acid 2-salicyloyloxy-benzoic acid Salicylsalicylic acid Saloxium Diacesal Salicylic Acid Bimolecular Ester Disalicylic acid Salicyl salicylate 2-{[(2-hydroxyphenyl)carbonyl]oxy}benzoic acid Diplosal Salina Salicylic Acid Salicylate carboxyphenyl salicylate Disalyl MFCD00020252 Salsalate sasapyrine Sasapyrinum

Description	Salsalate is a nonsteroidal anti-inflammatory drug (NSAID).Target：Salsalate is a medication that belongs to the salicylate and non-steroidal anti-inflammatory drug (NSAID) classes. Relative to other NSAIDs, Salsalate has a weak inhibitory effect on the cyclooxygenase enzyme and decreases the production of several pro inflammatory chemical signals such as interleukin-6, TNF-alpha, and C-reactive protein. Common conditions in which Salsalate may be indicated include inflammatory disorders such as rheumatoid arthritis or noninflammatory disorders such as osteoarthritis.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology

Density	1.4±0.1 g/cm3
Boiling Point	482.9±25.0 °C at 760 mmHg
Melting Point	139-151 °C
Molecular Formula	C₁₄H₁₀O₅
Molecular Weight	258.226
Flash Point	188.0±16.7 °C
Exact Mass	258.052826
PSA	83.83000
LogP	3.05
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.646
Storage condition	room temp

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH2080000

CHEMICAL NAME :: Benzoic acid, 2-hydroxy-, 2-carboxyphenyl ester

CAS REGISTRY NUMBER :: 552-94-3

BEILSTEIN REFERENCE NO. :: 2590908

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C14-H10-O5

MOLECULAR WEIGHT :: 258.24

WISWESSER LINE NOTATION :: QVR BOVR BQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 2229 mg/kg/2Y-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 107,116,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1020 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 22,1101,1980

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HBAMAK "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." (Leipzig, Ger. Dem. Rep.) Volume(issue)/page/year: 4,1289,1935 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 665 mg/kg

SEX/DURATION :: female 17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death Reproductive - Effects on Embryo or Fetus - other effects to embryo Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 29,250,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80509 No. of Facilities: 105 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3179 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80509 No. of Facilities: 34 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 629 (estimated) No. of Female Employees: 291 (estimated)

Symbol	GHS07, GHS09
Signal Word	Warning
Hazard Statements	H302-H400
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	37/39-26
RIDADR	3077.0
RTECS	DH2080000
HS Code	2918230000

Precursor 10
69-72-7 530-75-6 1466-82-6 36335-42-9
54-21-7 5538-51-2 50-78-2 486-58-8
123-91-1 623-11-0
DownStream 5
530-75-6 69-72-7 90510-23-9 537048-81-0
5853-89-4

HS Code	2918990090
Summary	2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%