Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: memantine hydrochloride
Price: ￥218.0/5g ￥658.0/25g
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Memantine Hydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Memantine hydrochloride
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Memantine HCl;Memantine Hydrochloride
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Memantine HCl
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

41100-52-1

41100-52-1 structure

Name: memantine hydrochloride
Chemical Name: memantine hydrochloride
CAS Number: 41100-52-1
Molecular Formula: C₁₂H₂₂ClN
Molecular Weight: 215.763
Catalog: Biochemical Inhibitor Neuronal Signaling AMPA Receptor-kainate Receptor-NMDA Receptor Inhibitor
Create Date: 2018-02-06 08:00:00
Modify Date: 2024-01-02 10:10:33
Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively..Target: NMDA Receptor, Memantine (Ebixa, Axura, Namenda, Akatinol) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type [1]. Memantine has considerable therapeutic potential for the myriad of clinical entities associated with NMDA receptor-mediated neurotoxicity [2]. Memantine blocked 200 microM NMDA-evoked responses with a 50% inhibition constant (IC50) of approximately 1 microM at -60 mV and an empirical Hill coefficient of approximately 1 [3].

Name	memantine hydrochloride
Synonyms	1,3-Dimethyl-5-aminoadamantane hydrochloride Axura 3,5-Dimethyl-1-adamantanamine Hydrochloride 3,5-Dimethyladamantan-1-amine hydrochloride (1:1) MFCD00214336 3,5-Dimethyltricyclo[3.3.1.1]decan-1-aminhydrochlorid Ebixza 1-Amino-3,5-dimethyladamantane Hydrochloride Tricyclo[3.3.1.1]decan-1-amine, 3,5-dimethyl-, hydrochloride (1:1) 3,5-dimethyltricyclo[3.3.1.1]decan-1-amine hydrochloride Memantine Hydrochloride 3,5-diméthyltricyclo[3.3.1.1]décan-1-amine chlorhydrate Tricyclo(3.3.1.1(3,7))decan-1-amine, 3,5-dimethyl-, hydrochloride Ebixia SUN Y7017 3,5-Dimethyl-1-adamantanamine hydrochloride (1:1) EINECS 255-219-6 tricyclo[3.3.1.1]decan-1-amine, 3,5-dimethyl-, hydrochloride 3,5-dimethyltricyclo[3.3.1.1]decan-1-amine hydrochloride (1:1) MemantineHCl 3,5-Dimethyladamantan-1-amine hydrochloride Memantine HCL Akatinol Menantine Hydrochloride Memantine (hydrochloride)

Description	Memantine, an amantadine derivative with low to moderate-affinity for NMDA receptors, inhibit CYP2B6 and CYP2D6 with Ki of 0.51 nM and 94.9 μM, respectively..Target: NMDA Receptor, Memantine (Ebixa, Axura, Namenda, Akatinol) is a moderate-affinity, uncompetitive, voltage-dependent, NMDA-receptor antagonist with fast on/off kinetics that inhibits excessive calcium influx induced by chronic overstimulation of the NMDA receptor. Memantine is approved in the US and the EU for the treatment of patients with moderate to severe dementia of the Alzheimer's type [1]. Memantine has considerable therapeutic potential for the myriad of clinical entities associated with NMDA receptor-mediated neurotoxicity [2]. Memantine blocked 200 microM NMDA-evoked responses with a 50% inhibition constant (IC50) of approximately 1 microM at -60 mV and an empirical Hill coefficient of approximately 1 [3].
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> Cytochrome P450 Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease
References	[1]. Robinson, D.M. and G.M. Keating, Memantine: a review of its use in Alzheimer's disease. Drugs, 2006. 66(11): p. 1515-34. [2]. Chen, H.S., et al., Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity. J Neurosci, 1992. 12(11): p. 4427-36. [3]. Chen, H.S. and S.A. Lipton, Mechanism of memantine block of NMDA-activated channels in rat retinal ganglion cells: uncompetitive antagonism. J Physiol, 1997. 499 ( Pt 1): p. 27-46.

Boiling Point	239.8ºC at 760 mmHg
Melting Point	292 °C
Molecular Formula	C₁₂H₂₂ClN
Molecular Weight	215.763
Flash Point	92.3ºC
Exact Mass	215.144073
PSA	26.02000
LogP	4.19640
Storage condition	-20°C Freezer

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2921300090

Precursor 10
19982-07-1 351329-88-9 19982-08-2 707-36-8
947238-46-2 1058345-42-8 702-79-4 75-05-8
707-37-9 941-37-7
DownStream 1
19982-08-2

HS Code	2921300090
Summary	2921300090 other cyclanic, cyclenic or cyclotherpenic mono- or polyamines, and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

41100-52-1	33103-93-4
356572-08-2	1329802-06-3
1189713-18-5	914296-81-4
56-99-5	6138-79-0
36625-96-4	1562338-39-9