- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Biotin-PFP ester
- Price: ￥4866.0/5g ￥1186.0/1g ￥476.0/250mg ￥316.0/100mg
- Purity: 95.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Biotin-PFP ester
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Biotin pentafluorophenyl ester
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
120550-35-8
120550-35-8 structure
- Name: Biotin-PFP ester
- Chemical Name: (2,3,4,5,6-pentafluorophenyl) 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate
- CAS Number: 120550-35-8
- Molecular Formula: C16H15F5N2O3S
- Molecular Weight: 410.359
- Catalog: Organic raw materials Organic fluorine compound Fluorophenol series
- Create Date: 2018-06-20 17:45:16
- Modify Date: 2024-01-02 17:03:50
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Biotin-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | (2,3,4,5,6-pentafluorophenyl) 5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate |
|---|---|
| Synonyms |
biotin-pentafluoro-phenyl ester
Pentafluorophenyl 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoate D-biotin pentafluorophenyl ester 1H-Thieno[3,4-d]imidazole-4-pentanoic acid, hexahydro-2-oxo-, 2,3,4,5,6-pentafluorophenyl ester, (3aS,4S,6aR)- (+)-Biotin-PFP-ester biotinylpentafluorophenyl ester Perfluorophenyl 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanoate PFP-Biotin |
| Description | Biotin-PFP ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
Alkyl/ether |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 555.3±50.0 °C at 760 mmHg |
| Melting Point | 190.0 to 194.0 °C |
| Molecular Formula | C16H15F5N2O3S |
| Molecular Weight | 410.359 |
| Flash Point | 289.6±30.1 °C |
| Exact Mass | 410.072357 |
| PSA | 92.73000 |
| LogP | 2.85 |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.513 |
| Storage condition | 2-8°C |
|
~98%
120550-35-8 |
| Literature: Korshun, Vladimir A.; Pestov, Nikolai B.; Nozhevnikova, Elena V.; Prokhorenko, Igor A.; Gontarev, Sergei V.; Berlin, Yuri A. Synthetic Communications, 1996 , vol. 26, # 13 p. 2531 - 2547 |
|
~95%
120550-35-8 |
| Literature: Chambers, Jennifer M.; Lindqvist, Lisa M.; Webb, Andrew; Huang, David C. S.; Savage, G. Paul; Rizzacasa, Mark A. Organic Letters, 2013 , vol. 15, # 6 p. 1406 - 1409 |
|
~80%
120550-35-8 |
| Literature: Stewart, Scott G.; Braun, Carlos J.; Polomska, Marta E.; Karimi, Mahdad; Abraham, Lawrence J.; Stubbs, Keith A. Organic and Biomolecular Chemistry, 2010 , vol. 8, # 18 p. 4059 - 4062 |
|
~96%
120550-35-8 |
| Literature: Rabinkov, A. G.; Pozdnev, V. F.; Amontov, S. V.; Kopelevich, V. M.; Gunar, V. I. Chemistry of Natural Compounds, 1989 , vol. 25, p. 350 - 353 Khimiya Prirodnykh Soedinenii, 1989 , # 3 p. 404 - 408 |
| Precursor 4 | |
|---|---|
| DownStream 2 | |
