Name | 1,3-dihydroxy-2-(hydroxymethyl)anthracene-9,10-dione |
---|---|
Synonyms |
Henine
1,3-dihydroxy-2-hydroxymethyl-9,10-anthraquinone 1,3-dihydroxy-2-hydroxymethyl-9,10-anthracenedione 1,3-Dihydroxy-2-(hydroxymethyl)-9,10-anthraquinone 1,3-dihydroxy-2-hydroxymethyl-anthraquinone Lucidin (quinone) 2-carbinol-1,3-dihydroxyanthraquinone Lucidin 9,10-Anthracenedione, 1,3-dihydroxy-2-(hydroxymethyl)- |
Description | Lucidin (NSC 30546) is a natural component of Rubia tinctorum L. lucidin is mutagenic in bacteria and mammalian cells.IC50 Value:Target: in vitro: Lucidin was mutagenic in five Salmonella typhimurium strains without metabolic activation, but the mutagenicity was increased after addition of rat liver S9 mix. In V79 cells, lucidin was mutagenic at the hypoxanthine-guanine phosphoribosyl transferase gene locus and active at inducing DNA single-strand breaks and DNA-protein cross-links as assayed by the alkaline elution method. Lucidin also induced DNA repair synthesis in primary rat hepatocytes and transformed C3H/M2-mouse fibroblasts in culture [1]. HPLC analysis of 32P-labelled DNA adducts revealed a peak co-migrating with an adduct obtained after in vitro treatment of deoxyguanosine-3'-phosphate with lucidin [2].in vivo: Dose-dependent increases in benign and malignant tumour formation were observed in the liver and kidneys of treated animals. 32P-post-labelling analysis showed an increase in the overall level of DNA adducts observed in the liver, kidney and colon of rats treated with 10% madder root in the diet for 2 weeks [2].Toxicity: lucidin is mutagenic in bacteria and mammalian cells [2].Clinical trial: |
---|---|
Related Catalog | |
References |
Density | 1.6±0.1 g/cm3 |
---|---|
Boiling Point | 585.0±29.0 °C at 760 mmHg |
Melting Point | 330ºC |
Molecular Formula | C15H10O5 |
Molecular Weight | 270.237 |
Flash Point | 321.6±20.8 °C |
Exact Mass | 270.052826 |
PSA | 94.83000 |
LogP | 2.79 |
Vapour Pressure | 0.0±1.7 mmHg at 25°C |
Index of Refraction | 1.746 |
Storage condition | -20°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATAMUTATION DATA
|
~% 478-08-0 |
Literature: Jegorov, Alexandr; Cvak, Ladislav; Cejka, Jan; Kratochvil, Bohumil; Sedmera, Petr; Havlicek, Vladimir Journal of Chemical Crystallography, 2005 , vol. 35, # 8 p. 621 - 627 |
~% 478-08-0 |
Literature: Tosa, Hideki; Iinuma, Munekazu; Asai, Fujio; Tanaka, Toshiyuki; Nozaki, Hiroshi; Ikeda, Shougo; Tsutsui, Ken; Tsutsui, Kimiko; Yamada, Masashi; Fujimori, Shiho Biological and Pharmaceutical Bulletin, 1998 , vol. 21, # 6 p. 641 - 642 |
~% 478-08-0 |
Literature: Joshi et al. Journal of Scientific and Industrial Research, 1955 , vol. 14 B, p. 87,92 |
Precursor 3 | |
---|---|
DownStream 7 | |