18323-58-5

18323-58-5 structure

Name: 4-Methylumbelliferyl Oleate
Chemical Name: 4-methylumbelliferyl oleate
CAS Number: 18323-58-5
Molecular Formula: C₂₈H₄₀O₄
Molecular Weight: 440.61500
Catalog: Research Areas Metabolic Disease
Create Date: 2018-05-11 08:00:00
Modify Date: 2024-01-04 20:19:21
4-Methylumbelliferyl oleate is a fluorogenic substrate for acid and alkaline lipases. 4-Methylumbelliferyl oleate is cleaved by lipases, liberating 4-Methylumbelliferyl (Ex/Em=320/450 nm)[1][2].

Name	4-methylumbelliferyl oleate
Synonyms	4-MethylumbelliferylOleateA.R. OLEIC ACID-4-METHYLUMBELLIFERYL ESTER Einecs 242-210-7 4-Methylumbelliferone oleate 7-Hydroxy-4-MethylcouMarin Oleate MFCD00076095 Oleic acid 4-methylumbelliferyl ester 4-methyl-2-oxo-2H-1-benzopyran-7-yl oleate Oleoyl 4-MethyluMbelliferone

Description	4-Methylumbelliferyl oleate is a fluorogenic substrate for acid and alkaline lipases. 4-Methylumbelliferyl oleate is cleaved by lipases, liberating 4-Methylumbelliferyl (Ex/Em=320/450 nm)[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	The inhibitory activity against pancreatic lipase was measured using 4-Methylumbelliferyl (4-MU) oleate as a substrate. The reaction mixture consisted of 50 µL 0.1 mM 4-MU oleate, 20 µL McIlvane buffer (0.1 M citrate-Na2 HPO4, pH 7.4), and 5 µL of sample solution. Porcine pancreatic lipase (25 µL) was added to the reaction mixture and the final volume was adjusted to 0.1 ml. After the mixture was incubated at 37℃ for 10 min, the amount of 4-MU released by the lipase was measured using a fluorescence multi-detection reader at an excitation wavelength of 320 nm and an emission wavelength of 450 nm[1].
References	[1]. Zhang J, et al. Pancreatic lipase inhibitory activity of taraxacum officinale in vitro and in vivo. Nutr Res Pract. 2008 Winter;2(4):200-3. [2]. Koster JF, et al. Study of the hydrolysis of 4-methylumbelliferyl oleate by acid lipase and cholesteryl oleate by acid cholesteryl esterase in human leucocytes, fibroblasts and liver. Biochim Biophys Acta. 1980 Apr 18;618(1):98-105.

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2932209090

90-33-5

112-80-1

~95%

18323-58-5

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%