158836-71-6
158836-71-6 structure
- Name: Nitroflurbiprofen
- Chemical Name: nitroflurbiprofen
- CAS Number: 158836-71-6
- Molecular Formula: C19H20FNO5
- Molecular Weight: 361.36400
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2017-01-07 02:37:29
- Modify Date: 2024-01-14 12:33:18
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Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats.
| Name | nitroflurbiprofen |
|---|---|
| Synonyms |
HCT-1026
4-nitrooxybutyl 2-(3-fluoro-4-phenylphenyl)propanoate NO-flurbiprofen Flurbiprofen nitroxybutyl ester Nitroxybutyl flurbiprofen Nitroflurbiprofen Flurbinitroxybutylester |
| Description | Nitroflurbiprofen is a cyclooxygenase (COX) inhibitor with nitric oxide (NO)-donating properties, modulates the increased intrahepatic vascular tone in portal hypertensive cirrhotic rats. |
|---|---|
| Related Catalog | |
| Target |
COX |
| In Vivo | In vivo hemodynamic measurements (n = 8/condition) and evaluation of the increased intrahepatic resistance by in situ perfusion (n=5/condition) are performed in rats with thioacetamide-induced cirrhosis that receive either Nitroflurbiprofen (45 mg/kg), Flurbiprofen (30 mg/kg, equimolar concentration to Nitroflurbiprofen), or vehicle by intraperitoneal injection 24 hours and 1 hour prior to the measurements. Treatment with Nitroflurbiprofen, an NO-releasing cyclooxygenase inhibitor, improves portal hypertension without major adverse effects in thioacetamide-induced cirrhotic rats by attenuating intrahepatic vascular resistance, endothelial dysfunction, and hepatic hyperreactivity to vasoconstrictors[1]. |
| Animal Admin | Rats[1] Male Wistar rats, weighing 200-250 g, are used. After 18 weeks of TAA administration, cirrhotic rats are equally (n=8/group) and randomly allocated to one of the following groups: intraperitoneal injection, 24 hours and 1 hour prior to the measurements, with Nitroflurbiprofen (45 mg/kg), Flurbiprofen (30 mg/kg, equimolar concentration to Nitroflurbiprofen), or vehicle (250 μL DMSO:250 μL isotonic saline). The used dose is based on a dose-finding study (n=5 per condition). The concentrations of Nitroflurbiprofen (15 mg/kg) and Flurbiprofen (7.5 mg/kg, equimolar concentration to Nitroflurbiprofen Flurbiprofen) are started, then are increased the dose to Nitroflurbiprofen 22.5 mg/kg and Flurbiprofen 15 mg/kg, and, finally, Nitroflurbiprofen 45 mg/kg and Flurbiprofen 30 mg/kg. The last dose regimen has the most profound hemodynamic effects. |
| References |
| Density | 1.214g/cm3 |
|---|---|
| Boiling Point | 468.8ºC at 760 mmHg |
| Molecular Formula | C19H20FNO5 |
| Molecular Weight | 361.36400 |
| Flash Point | 237.3ºC |
| Exact Mass | 361.13300 |
| PSA | 81.35000 |
| LogP | 4.65110 |
| Vapour Pressure | 5.79E-09mmHg at 25°C |
| Index of Refraction | 1.537 |
| Storage condition | 2-8℃ |