203784-52-5

203784-52-5 structure

Name: Nortriptyline-d3 hydrochloride
Chemical Name: 3-(5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)-N-(trideuteriomethyl)propan-1-amine,hydrochloride
CAS Number: 203784-52-5
Molecular Formula: C₁₉H₁₉ClD₃N
Molecular Weight: 302.856
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2018-03-12 08:00:00
Modify Date: 2024-01-13 18:12:34
Nortriptyline-d3 (Desmethylamitriptyline-d3) hydrochloride is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression[1].

Name	3-(5,6-dihydrodibenzo[2,1-b:2',1'-f][7]annulen-11-ylidene)-N-(trideuteriomethyl)propan-1-amine,hydrochloride
Synonyms	Nortrilen-d3 Pamelor-d3 Norzepine-d3 Nortriptyline-d3 Hydrochloride Allegron-d3 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-(H)methyl-1-propanamine hydrochloride (1:1) Acetexa-d3 Sensival-d3 3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-(H)methylpropan-1-amine hydrochloride (1:1) Vividyl-d3 1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-(methyl-d)-, hydrochloride (1:1)

Description	Nortriptyline-d3 (Desmethylamitriptyline-d3) hydrochloride is the deuterium labeled Nortriptyline hydrochloride. Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and used to relieve the symptoms of depression[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Neurological Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23.