Name | 2',5'-Dihydroxyacetophenone |
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Synonyms |
Ethanone, 1- (2,5-dihydroxyphenyl)-
2,5-Dihydroxyphenyl methyl ketone,2-Acetyl-1,4-dihydroxybenzene,2-Acetylhydroquinone 2’,5’-Dihydroxyacetophenone 1-(2,5-Dihydroxyphenyl)ethanone 2',5'-Dihydroxyacetophenone 2',5'-Dihydroxy acetophenone Quinacetophenone EINECS 207-716-4 2-Acetylhydroquinone 2‘,5‘-Dihydroxyacetophenone Ethanone, 1-(2,5-dihydroxyphenyl)- MFCD00002343 |
Description | 2,5-Dihydroxyacetophenone, isolated from Rehmanniae Radix Preparata, inhibits the production of inflammatory mediators in activated macrophages by blocking the ERK1/2 and NF-κB signaling pathways[1]. |
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Related Catalog | |
Target |
ERK1 ERK2 NF-κB |
In Vitro | 2,5-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression and significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 via the down-regulation of their mRNA expression in LPS-stimulated RAW264.7 cells. 2,5-Dihydroxyacetophenone potently inhibits the phosphorylation of extracellular signal-related kinase (ERK) 1/2 and the nuclear translocation of nuclear factor-κB (NF-κB) p65 in LPS-stimulated cells[1]. |
References |
Density | 1.3±0.1 g/cm3 |
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Boiling Point | 329.2±27.0 °C at 760 mmHg |
Melting Point | 204-206 °C(lit.) |
Molecular Formula | C8H8O3 |
Molecular Weight | 152.147 |
Flash Point | 167.1±20.2 °C |
Exact Mass | 152.047348 |
PSA | 57.53000 |
LogP | 1.59 |
Vapour Pressure | 0.0±0.7 mmHg at 25°C |
Index of Refraction | 1.595 |
Water Solubility | insoluble |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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Hazard Codes | Xi:Irritant |
Risk Phrases | R36/37/38 |
Safety Phrases | S26-S36 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
RTECS | AM7700000 |
HS Code | 29145000 |
Precursor 10 | |
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DownStream 9 | |
HS Code | 2914501900 |
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Summary | 2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |