59-02-9

59-02-9 structure

Name: DL-alpha-Tocopherol
Chemical Name: (+)-α-tocopherol
CAS Number: 59-02-9
Molecular Formula: C₂₉H₅₀O₂
Molecular Weight: 430.706
Catalog: Pharmaceutical intermediate Heterocyclic compound Pyridine compound Pyridine derivative
Create Date: 2018-09-09 15:38:01
Modify Date: 2024-01-02 23:06:20
(+)-α-Tocopherol is a vitamin E derivative. vitamin E is a fat-soluble antioxidant.

Name	(+)-α-tocopherol
Synonyms	Viterra E (2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-ol Juvela Food 500 Med-E Denamone D-a tocopherol (2R,4'R,8'R)-a-Tocopherol Renascin a-Tocopherol Syntopherol [2R-2R(4R,8R*)]-3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol Tokopharm α-Tokoferol EINECS 200-412-2 Profecundin (+)-α-tocopherol Etavit Rontex 201 Rocavit E Vascuals Epsilan Lan-E (2R,4'R,8'R)-2,5,7,8-Tetramethyl-2-(4',8',12'-trimethyltridecyl)-6-chromanol Tenox GT 1 VITEOLIN (all-R)-α-Tocopherol Fujimix E 20N (R,R,R)-a-Tocopherol Phytogermine Etamican Viprimol (2R,4'R,8'R)-α-Tocopherol (R)-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-3,4-dihydro-2H-chromen-6-ol Almefrol Endo E MFCD00072045 α-Tocopherol Irganox E 217 Irganox E 218 D-α tocopherol Vitamin E α Esorb D-α-Tocopherol Rhenogran Ronotec 50 (2R)-2,5,7,8-Tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-6-chromanol (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL Aquasol E Vitaplex E Juvela E Erevit forte α-Tocopherol acid (2R)-3,4-Dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol Vitamin E Vi-E E-Mix 40 (all-R)-a-Tocopherol Antisterility vitamin Covitol E Prolin Palmvitee Verrol Emipherol 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-, (2R)- a-Tocopherol Acid Irganox E 201 Ilitia Spavit E covi-ox E-Oil 1000 (+)-a-Tocopherol (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydro-2H-chromen-6-ol Covitol F 1300 Vitayonon Hydrovit E forte Juvela nicotinate 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-((4R,8R)-4,8,12-trimethyltridecyl)-, (2R)- a-Tokoferol (+)-alpha-tocopherol

Description	(+)-α-Tocopherol is a vitamin E derivative. vitamin E is a fat-soluble antioxidant.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Others Research Areas >> Cancer Research Areas >> Infection
References	[1]. Geissler RG, et al. In vitro improvement of bone marrow-derived hematopoietic colony formation in HIV-positive patients by alpha-D-tocopherol and erythropoietin. Eur J Haematol. 1994 Oct;53(4):201-6.

Density	0.9±0.1 g/cm3
Boiling Point	485.9±0.0 °C at 760 mmHg
Melting Point	2.5-3.5ºC
Molecular Formula	C₂₉H₅₀O₂
Molecular Weight	430.706
Flash Point	210.2±24.4 °C
Exact Mass	430.381073
PSA	29.46000
LogP	11.90
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.495

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DJ2900000

CHEMICAL NAME :: 2H-1-Benzopyran-6-ol, 3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltr idecyl)-, (2R-(2R*(4R*,8R*)))-

CAS REGISTRY NUMBER :: 59-02-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C29-H50-O2

MOLECULAR WEIGHT :: 430.79

WISWESSER LINE NOTATION :: T66 BOT&J C3Y1&3Y1&3Y1&1 C1 G1 HQ I1 J1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 7500 mg/kg

SEX/DURATION :: female 1-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - other measures of fertility

TYPE OF TEST :: DNA adduct

MUTATION DATA

TYPE OF TEST :: DNA inhibition

TEST SYSTEM :: Rodent - rat Liver

DOSE/DURATION :: 100 umol/L

REFERENCE :: CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 45,337,1985 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5582 No. of Facilities: 279 (estimated) No. of Industries: 4 No. of Occupations: 8 No. of Employees: 6957 (estimated) No. of Female Employees: 3599 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	S23-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	DJ2900000
HS Code	2936280000

Precursor 9
505-32-8 700-13-0 71-36-3 105-58-8
110-19-0 78-93-3 32466-45-8 14745-36-9
113348-75-7
DownStream 10
54-28-4 40516-48-1 40516-49-2 527-18-4
489-01-0 23531-69-3 100-09-4 1707-75-1
216210-47-8 2387-23-7

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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