686770-80-9

686770-80-9 structure

Name: BC-11-38
Chemical Name: bc11-38
CAS Number: 686770-80-9
Molecular Formula: C₁₅H₁₆N₂OS₂
Molecular Weight: 304.43000
Catalog: Signaling Pathways Metabolic Enzyme/Protease Phosphodiesterase (PDE)
Create Date: 2017-01-04 22:26:03
Modify Date: 2024-01-04 21:20:22
BC11-38 is a potent, selective, and biologically active PDE11 inhibitor, with IC50s of 0.28 µM and >100 µM for PDE11 and PDE1-10, respectively. BC11-38 elevates cAMP levels, PKA-mediated ATF-1 phosphorylation, and cortisol production in H295R cells[1].

Name	bc11-38
Synonyms	bc 11-38

Description	BC11-38 is a potent, selective, and biologically active PDE11 inhibitor, with IC50s of 0.28 µM and >100 µM for PDE11 and PDE1-10, respectively. BC11-38 elevates cAMP levels, PKA-mediated ATF-1 phosphorylation, and cortisol production in H295R cells[1].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Target	PDE11:0.28 μM (IC50)
In Vitro	BC11-38 (20 μM; hours) elevate cAMP levels in H295R adrenocortical cells[1].
References	[1]. Ceyhan O, et al. Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen. Chem Biol. 2012;19(1):155-163.