BioBioPha
China
Product Name: Gelsemine
Price: ￥Inquiry/5mg
Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Gelsemine
Price: ￥1258.0/20mg
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: Gelsemine
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Henan Tianfu Chemical Co., Ltd.
China
Product Name: GELSEMINE
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
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Contact: Anson

509-15-9

509-15-9 structure

509-15-9 structure

Name: Gelsemine
Chemical Name: Gelsemine
CAS Number: 509-15-9
Molecular Formula: C₂₀H₂₂N₂O₂
Molecular Weight: 322.401
Catalog: Natural product Alkaloid
Create Date: 2018-08-02 17:48:58
Modify Date: 2024-01-05 01:34:41
Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans, is effective in mitigating chronic pain. Antinociceptive and hypnotic effects.

Name	Gelsemine
Synonyms	GELSAMINE 8abeta,9s,10s))-8alph GESEMINE (2'S,3S,5'S,6'R,8'R,11'S)-4'-Methyl-2'-vinylspiro[indole-3,7'-[9]oxa[4]azatetracyclo[6.3.1.0.0]dodecan]-2(1H)-one gelsemine free base Gelsemin EINECS 208-095-2

Description	Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans, is effective in mitigating chronic pain. Antinociceptive and hypnotic effects.
Related Catalog	Signaling Pathways >> Others >> Others Natural Products >> Alkaloid Research Areas >> Neurological Disease
In Vivo	Gelsemine is an effective agent for treatment of both neuropathic pain and sleep disturbance in partial sciatic nerve ligation (PSNL) mice. Gelsemine (4 mg/kg) exerts analgesic effects on PSNL-induced mechanical allodynia and thermal hyperalgesia. In PSNL mice, Gelsemine (2 and 4 mg/kg) increases the mechanical threshold for 4 h and prolonged the thermal latencies for 3 h. Furthermore, Gelsemine (4 mg/kg, administered at 6:30 AM) increases non-rapid eye movement (non-REM, NREM) sleep, decreases wakefulness, but does not affect rapid eye movement (REM) sleep during the first 3 h in PSNL mice[1]. Immunohistochemical study shows that PSNL increases c-Fos expression in the neurons of the anterior cingulate cortex, and Gelsemine (4 mg/kg) decreases c-Fos expression by 58%[1].
References	[1]. Wu YE, et al. Gelsemine alleviates both neuropathic pain and sleep disturbance in partial sciatic nerve ligation mice. Acta Pharmacol Sin. 2015 Nov;36(11):1308-17.

Density	1.3±0.1 g/cm3
Boiling Point	493.4±45.0 °C at 760 mmHg
Melting Point	181-183ºC
Molecular Formula	C₂₀H₂₂N₂O₂
Molecular Weight	322.401
Flash Point	252.2±28.7 °C
Exact Mass	322.168121
PSA	41.57000
LogP	3.08
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.673

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LX9100000

CHEMICAL NAME :: Gelsemine

CAS REGISTRY NUMBER :: 509-15-9

BEILSTEIN REFERENCE NO. :: 5406576

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C20-H22-N2-O2

MOLECULAR WEIGHT :: 322.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DUSA** "Dispensatory of the United States of America," 24th ed., Osol, A. and G.E. Farrar, Philadelphia, J.B. Lippincott Co., 1947 Volume(issue)/page/year: 24,497,1947

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 49 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 7,349,1957

Hazard Codes	T+
Risk Phrases	23/24/25-26/27/28
Safety Phrases	36/37/39-45-28
RIDADR	UN 1544 6.1/PG 2
WGK Germany	3
RTECS	LX9100000
Packaging Group	I
Hazard Class	6.1(a)

Precursor 1
55856-53-6
DownStream 0