312917-14-9

312917-14-9 structure

Name: TCS JNK 5a
Chemical Name: N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide
CAS Number: 312917-14-9
Molecular Formula: C₂₀H₁₆N₂OS
Molecular Weight: 332.419
Catalog: Biochemical Inhibitor Mitogen-activated protein kinase (MAPK) JNK inhibitor
Create Date: 2018-12-27 19:24:45
Modify Date: 2024-01-03 14:21:14
TCS JNK 5a is a potent JNK3 inhibitor with a pIC50 of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC50 of 6.5.

Name	N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide
Synonyms	F0016-0404 1-Naphthalenecarboxamide, N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thien-2-yl)- N-(3-cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)naphthalene-1-carboxamide JNK Inhibitor IX N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-1-naphthamide TCS JNK 5a SC-20267 N-(3-Cyano-4,5,6,7-tetrahydrobenzo[b]thienyl-2-yl)-1-naphthalenecarboxamide

Description	TCS JNK 5a is a potent JNK3 inhibitor with a pIC50 of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC50 of 6.5.
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> JNK Research Areas >> Cancer
Target	JNK3:6.7 (pIC50) JNK2:6.5 (pIC50)
In Vitro	TCS JNK 5a is also screened in a panel of more than 30 kinase assays, including Alk5, c-Fms, CDK-2, EGFR, ErbB2, GSK3β, PLK1, Src, Tie-2 and VegFr2, and is inactive (pIC50<5.0) against all of them[1].
References	[1]. Angell RM, et al. N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1296-301.