251945-92-3

251945-92-3 structure

Name: SLV 320
Chemical Name: 4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexan-1-ol
CAS Number: 251945-92-3
Molecular Formula: C₁₈H₂₀N₄O
Molecular Weight: 308.37800
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2018-12-21 12:20:22
Modify Date: 2024-01-16 14:25:03
Derenofylline is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2Areceptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats[1].

Name	4-[(2-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclohexan-1-ol
Synonyms	UNII-O1Q96UZ63W SLV 320 Derenofylline

Description	Derenofylline is a potent, selective and orally active adenosine A1 receptor antagonist, with Ki values of 1 nM, 200 nM and 398 nM for human A1, A3 and A2Areceptors respectively. Derenofylline suppresses cardiac fibrosis and attenuates albuminuria without affecting blood pressure in rats[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor
Target	Ki: 1 nM (adenosine A1 receptor)[1].
References	[1]. Kalk P, et al. The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure. Br J Pharmacol. 2007 Aug;151(7):1025-32.