250249-75-3

250249-75-3 structure

Name: Rutoside Trihydrate
Chemical Name: Rutin trihydrate
CAS Number: 250249-75-3
Molecular Formula: C₂₀H₃₆O₃
Molecular Weight: 324.49800
Catalog: analytical chemistry Analytical reagent Ion chromatography reagent
Create Date: 2018-02-23 08:00:00
Modify Date: 2024-01-04 12:46:08
Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. Rutin trihydrate has been demonstrating excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. Cardioprotective and neuroprotective activities [1][2][3].

Name	Rutin trihydrate
Synonyms	Rutoside trihydrate MFCD00149490 EINECS 205-814-1 Quercetin-3-rutinoside trihydrate,Vitamin P trihydrate

Description	Rutin (Rutoside) trihydrate is a multifunctional natural flavonoid glycoside. Rutin trihydrate has been demonstrating excellent antioxidant, anti-inflammatory, anti-diabetic, and anti-carcinogenic properties. Cardioprotective and neuroprotective activities [1][2][3].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	Rutin (Rutoside) trihydrate (0.5- 160 μM/ml; PC12 cells) decreases the acrylamide (ACR)-induced (5.46 mM) cytotoxicity significantly. ACR (5.46 mM) decreases cell viability in PC12 cells and pretreatment with rutin (0.5, 1, 1.5, 2.5, 5, 10, 20 and 40 μM/ml) increases the cell viability[2]. Due to the ability of Rutin and/or its metabolites to cross the blood brain barrier, it has also been shown to modify the cognitive and various behavioral symptoms of neurodegenerative diseases[3].
In Vivo	Pretreatment of Rutin (100 and 200 mg/kg/day; i.p.) for long-term caused behavioural and neurochemical changes in aged WAG male rats[2].
References	[1]. Mel MMRD, et al. Formulation of microencapsulated rutin and evaluation of bioactivity and stability upon in vitro digestive and dialysis conditions. Int J Biol Macromol. 2020;159:316-323. [2]. Doostkam A, et al. Effect of Rutin on Diabetic Auditory Neuropathy in an Experimental Rat Model. Clin Exp Otorhinolaryngol. 2021;14(3):259-267. [3]. Habtemariam S. Rutin as a Natural Therapy for Alzheimer's Disease: Insights into its Mechanisms of Action. Curr Med Chem. 2016;23(9):860-873.

Density	1.82g/cm3
Boiling Point	983.1ºC at 760mmHg
Melting Point	195ºC
Molecular Formula	C₂₀H₃₆O₃
Molecular Weight	324.49800
Flash Point	325.4ºC
Exact Mass	324.26600
PSA	27.69000
LogP	6.34500
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.764

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn: Harmful;
Risk Phrases	22
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport

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