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Product Name: Phenprocoumon (Marcumar)
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Dayang Chem (Hangzhou) Co., Ltd.
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Product Name: phenprocoumon
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Purity: 98.0%
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435-97-2

435-97-2 structure

435-97-2 structure

Name: Phenprocoumon
Chemical Name: phenprocoumon
CAS Number: 435-97-2
Molecular Formula: C₁₈H₁₆O₃
Molecular Weight: 280.318
Catalog: Research Areas Others
Create Date: 2018-06-28 17:25:23
Modify Date: 2024-01-02 17:07:36
Phenprocoumon is a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K.

Name	phenprocoumon
Synonyms	Marcoumar Phenprocumon Marcumar 4-Hydroxy-3-(1-phenylpropyl)-2H-chromen-2-one UNII:Q08SIO485D Falithrom Falithiom Phenprocumone 3-(a-Ethylbenzyl)-4-hydroxycoumarin 2H-1-Benzopyran-2-one, 4-hydroxy-3-(1-phenylpropyl)- RO 1-4849 Fencumar LIQUAMAR PHENPROCOUMON

Description	Phenprocoumon is a coumarin derivative that acts as a long acting oral anticoagulant and an antagonist of vitamin K.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Others
Target	Vitamin K[1].
In Vivo	After a single i.v.-dose of phenprocoumon (0.355 mg/kg) the anticoagulant effect obtained is greater in older than in younger rats. There are no differences between younger and older rats in the rate of elimination, volume of distribution and in the free fraction and free concentration values of phenprocoumon in plasma and liver. After i.v.-injection of 64.3 μg/kg [3H]vitamin K1 and different doses of phenprocoumon (0.02 to 3 mg/kg) the [3H]vitamin K1 concentration in the liver decreases and the [3H] vitamin K1-2, 3-epoxide concentration increases dependent on the dose and the liver concentration of phenprocoumon. These changes are more pronounced in the older than in the younger rats[2].
References	[1]. Straubhaar B, et al. The prevalence of potential drug-drug interactions in patients with heart failure at hospital discharge. Drug Saf. 2006;29(1):79-90. [2]. DIETMAR TRENK, et al. Age-dependent differences in the effect of phenprocoumon on the vitamin K1-epoxide cycle in rats. Trenk D. J Pharm Pharmacol. 1980 Dec;32(12):828-32.

Density	1.3±0.1 g/cm3
Boiling Point	463.2±45.0 °C at 760 mmHg
Melting Point	179.5ºC
Molecular Formula	C₁₈H₁₆O₃
Molecular Weight	280.318
Flash Point	195.7±21.5 °C
Exact Mass	280.109955
PSA	50.44000
LogP	4.77
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.638
Storage condition	2-8℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GN6769000

CHEMICAL NAME :: Coumarin, 3-(alpha-ethylbenzyl)-4-hydroxy-

CAS REGISTRY NUMBER :: 435-97-2

BEILSTEIN REFERENCE NO. :: 1291115

LAST UPDATED :: 199612

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C18-H16-O3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 222,107,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 190 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 222,107,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 32 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 222,107,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 222,107,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 62 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 222,107,1954 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 13500 ug/kg/26W-I

TOXIC EFFECTS :: Blood - hemorrhage Blood - change in clotting factors Related to Chronic Data - death

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,145,1971

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 24900 ug/kg/52W-I

TOXIC EFFECTS :: Related to Chronic Data - death

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,145,1971

RIDADR	UN 2811
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2932209090

1076-38-6 structure

1076-38-6

93-54-9 structure

93-54-9

~95%

435-97-2 structure

435-97-2

Literature: Kischel, Jette; Mertins, Kristin; Michalik, Dirk; Zapf, Alexander; Beller, Matthias Advanced Synthesis and Catalysis, 2007 , vol. 349, # 6 p. 865 - 870

Precursor 2
1076-38-6 93-54-9
DownStream 0

HS Code	2932209090
Summary	2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%