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9064-57-7

9064-57-7 structure

9064-57-7 structure

Name: GAMMA-CARRAGEENAN
Chemical Name: λ-carrageenan
CAS Number: 9064-57-7
Molecular Formula: C₂₄H₃₆O₃₉S₆
Molecular Weight: 1140.91000
Catalog: Research Areas Cancer
Create Date: 2018-07-22 16:11:39
Modify Date: 2024-01-14 18:06:46
λ-Carrageenan is a seaweed polysaccharide which has been generally used as proinflammatory agent in the basic research. λ-Carrageenan is a potent antitumor agent[1].

Name	λ-carrageenan
Synonyms	MFCD00151513 lambda-carrageenan λ-Carrageenan 2-O-Sulfonato-β-D-galactopyranosyl-(1->4)-2,6-di-O-sulfonato-α-D-galactopyranosyl-(1->3)-2-O-sulfonato-β-D-galactopyranosyl-(1->4)-2,6-di-O-sulfonato-α-D-galactopyranose

Description	λ-Carrageenan is a seaweed polysaccharide which has been generally used as proinflammatory agent in the basic research. λ-Carrageenan is a potent antitumor agent[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vivo	λ-Carrageenan (50 mg/kg every two days; intratumoral injection) inhibits tumor growth in B16-F10 and 4T1 bearing mice[1]. λ-carrageenan exhibits considerable antitumor effect via intratumoral injection and significantly improves the tumor immune response with increased infiltrates of immunostimulating cells and increases production of proinflammatory cytokines[1].
References	[1]. Luo M, et al. Antitumor and Adjuvant Activity of λ-carrageenan by Stimulating Immune Response in Cancer Immunotherapy. Sci Rep. 2015;5:11062. Published 2015 Jun 22.

Molecular Formula	C₂₄H₃₆O₃₉S₆
Molecular Weight	1140.91000
Exact Mass	1139.92000
PSA	675.31000

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FI0704000

CHEMICAL NAME :: lambda-Carrageenan

CAS REGISTRY NUMBER :: 9064-57-7

LAST UPDATED :: 199512

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Vascular - thrombosis distant from injection site Liver - hepatitis (hepatocellular necrosis), zonal Liver - other changes

REFERENCE :: BJEPA5 British Journal of Experimental Pathology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1920- Volume(issue)/page/year: 57,455,1976

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Blood - change in clotting factors

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 17,647,1965

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
RTECS	FI0704000