480-11-5

480-11-5 structure

Name: oroxylin A
Chemical Name: oroxylin A
CAS Number: 480-11-5
Molecular Formula: C₁₆H₁₂O₅
Molecular Weight: 284.263
Catalog: Natural product Flavonoids
Create Date: 2018-07-04 22:50:41
Modify Date: 2024-01-02 12:46:03
Oroxylin A is a natural active flavonoid with strong anticancer effects.IC50 value:Target:In vitro: Oroxylin A suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 transcription in wt-p53 cancer cells [1]. Oroxylin A remarkably reduced the generation of lactate and glucose uptake under hypoxia in HepG2 cells, inhibited HIF-1α expression and its stability [2]. Oroxylin A promotes superoxide dismutase (SOD2) gene expression through SIRT3-regulated DNA-binding activity of FOXO3a and increases the activity of SOD2 by promoting SIRT3-mediated deacetylation [3]. In vivo: Oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression of MDM2 protein in tumor tissue was downregulated by oroxylin A as well [1].

Name	oroxylin A
Synonyms	Oroxylin 4H-1-Benzopyran-4-one, 5,7-dihydroxy-6-methoxy-2-phenyl- baicalein 6-methyl ether 5,7-Dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one 5,7-Dihydroxy-6-methoxyflavone 6-Methoxybaicalein oroxyllin-A 6-methoxy-5,7-dihydroxyflavone 5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one oroxylin A 5,7-Dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one 5,7-Dihydroxy-6-methoxyflavone 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one 4H-1-Benzopyran-4-one,5,7-dihydroxy-6-methoxy-2-phenyl

Description	Oroxylin A is a natural active flavonoid with strong anticancer effects.IC50 value:Target:In vitro: Oroxylin A suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 transcription in wt-p53 cancer cells [1]. Oroxylin A remarkably reduced the generation of lactate and glucose uptake under hypoxia in HepG2 cells, inhibited HIF-1α expression and its stability [2]. Oroxylin A promotes superoxide dismutase (SOD2) gene expression through SIRT3-regulated DNA-binding activity of FOXO3a and increases the activity of SOD2 by promoting SIRT3-mediated deacetylation [3]. In vivo: Oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression of MDM2 protein in tumor tissue was downregulated by oroxylin A as well [1].
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Metabolic Enzyme/Protease >> HIF/HIF Prolyl-Hydroxylase Research Areas >> Cancer Natural Products >> Flavonoids
References	[1]. Zhao K, et al. Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells. J Hematol Oncol. 2015 Apr 23;8:41. http://www.ncbi.nlm.nih.gov/pubmed/25902914 [2]. Dai Q, et al. Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia-inducible factor-1 in human hepatoma HepG2 cells. Mol Carcinog. 2015 Aug 10. [3]. Wei L, et al. Oroxylin A inhibits glycolysis-dependent proliferation of human breast cancer via promoting SIRT3-mediated SOD2 transcription and HIF1α destabilization. Cell Death Dis. 2015 Apr 9

Density	1.4±0.1 g/cm3
Boiling Point	540.9±50.0 °C at 760 mmHg
Melting Point	195-197ºC
Molecular Formula	C₁₆H₁₂O₅
Molecular Weight	284.263
Flash Point	207.4±23.6 °C
Exact Mass	284.068481
PSA	79.90000
LogP	2.37
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.669
Storage condition	2-8°C

Hazard Codes	Xn
Risk Phrases	22

Precursor 10
973-67-1 2035-05-4 491-67-8 74-88-4
642-71-7 22248-14-2 571168-66-6 70185-52-3
100-52-7 102-92-1
DownStream 3
491-67-8 973-67-1 740-33-0

480-11-5	36948-76-2
36948-77-3	82475-02-3
82475-01-2	5331-17-9
109291-57-8	2041789-14-2
145458-91-9	13828-23-4