- Sichuan Hengkang Science and Technology Development Co.,Ltd.
- China
- Product Name: Boc-L-Hydroxyproline cas：13726-69-7
- Price: ￥Inquiry/1kg ￥Inquiry/1ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Teresa
- GL Biochem (Shanghai) Ltd.
- China
- Product Name: Boc-Hyp-OH
- Price: ￥Inquiry/1kg ￥Inquiry/100g
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Jackie Yang
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Boc-Hyp-OH
- Price: ￥1998.0/1kg ￥278.0/100g ￥98.0/25g ￥1998.0/1kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Liu jia
- Chengdu Pukang Biotechnology Co., Ltd.
- China
- Product Name: Boc-Hyp-OH
- Price: ￥Inquiry/10g
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Lihua Yang
- DC Chemicals Limited
- China
- Product Name: Boc-Hyp-OH
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
13726-69-7
13726-69-7 structure
- Name: Boc-Hyp-OH
- Chemical Name: Boc-L-Hydroxyproline
- CAS Number: 13726-69-7
- Molecular Formula: C10H17NO5
- Molecular Weight: 231.246
- Catalog: Biochemical Amino acids and their derivatives Proline derivatives
- Create Date: 2018-07-09 18:23:20
- Modify Date: 2024-01-01 19:54:48
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Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]
| Name | Boc-L-Hydroxyproline |
|---|---|
| Synonyms |
1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2S)-
trans-N-(tert-Butoxycarbonyl)-4-hydroxy-L-proline BOC-HYP-OH N-ter trans-Boc-Hyp-OH BOC-L-HYP-OH BOC-HYP N-BOC-L-Hydroxyproline RARECHEM EM WB 0136 trans-N-tert-Butoxycarbonyl-4-hydroxy-l-proline BOC-L-4-HYDROXYPROLINE BOC-trans-4-hydroxy-L-proline BOC-TRANS-HYP-OH 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) ester, (2S,4R)- (2S,4R)-1-(tert-Butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid MFCD00053370 trans-N-Boc-4-hydroxy-L-proline BOC-HYDROXYPROLINE (4R)-4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline 4-Hydroxy-1-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-proline 1-(tert-Butoxycarbonyl)-4-hydroxy-L-proline |
| Description | Boc-Hyp-OH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-Hyp-OH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2] |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 390.9±42.0 °C at 760 mmHg |
| Melting Point | 123-127 °C(lit.) |
| Molecular Formula | C10H17NO5 |
| Molecular Weight | 231.246 |
| Flash Point | 190.2±27.9 °C |
| Exact Mass | 231.110672 |
| PSA | 87.07000 |
| LogP | -0.71 |
| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
| Index of Refraction | 1.531 |
| Storage condition | -20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xn |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2933990090 |
| Precursor 10 | |
|---|---|
| DownStream 10 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |