400044-47-5

400044-47-5 structure

Name: UK-396082
Chemical Name: (2S)-5-amino-2-[(1-propylimidazol-4-yl)methyl]pentanoic acid
CAS Number: 400044-47-5
Molecular Formula: C₁₂H₂₁N₃O₂
Molecular Weight: 239.31400
Catalog: Research Areas Metabolic Disease
Create Date: 2017-11-28 16:55:00
Modify Date: 2024-02-01 15:34:23
UK‑396082 is a potent thrombin activated fibrinolytic inhibitor (TAFI) inhibitor. UK‑396082 increases plasmin activity and induces a parallel decrease in ECM levels. UK‑396082 can be used in research of chronic kidney disease (CKD)[1].

Name	(2S)-5-amino-2-[(1-propylimidazol-4-yl)methyl]pentanoic acid
Synonyms	(2s)-5-Amino-2-[(1-Propyl-1h-Imidazol-4-Yl)methyl]pentanoic Acid UK-396,082 UNII-2Q5861SUIG

Description	UK‑396082 is a potent thrombin activated fibrinolytic inhibitor (TAFI) inhibitor. UK‑396082 increases plasmin activity and induces a parallel decrease in ECM levels. UK‑396082 can be used in research of chronic kidney disease (CKD)[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
In Vitro	UK‑396082 (0-1000 nM; NRK52E 细胞; 96 小时) 以剂量依赖性方式诱导 TAFI 活性[1]。 UK‑396082 (500 nM; 24 h) 增加 NRK52E 细胞 (+109%) 和 NRK49F 成纤维细胞 (+38.3%) 中的纤溶酶活性[1]。 UK‑396082 (500 nM; 24 h; NRK52E 细胞) 使 ECM 水平降低 46%[1]。
References	[1]. Atkinson JM, et, al. An inhibitor of thrombin activated fibrinolysis inhibitor (TAFI) can reduce extracellular matrix accumulation in an in vitro model of glucose induced ECM expansion. Matrix Biol. 2013 Jun 24;32(5):277-87.