Name | α-linolenic acid |
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Synonyms |
EINECS 207-334-8
(9Z,12Z,15Z)-linolenic acid 9,12,15-all-cis-Octadecatrienoic acid 9,12,15-Octadecatrienoic acid, (9Z,12Z,15Z)- Linolein,2-mono 2-linoleoyl-sn-glycerol 2-Monolinolein (9Z,12Z,15Z)-Octadeca-9,12,15-trienoic acid 2-Glyceryl 9,12-octadecadienoate 9,12-Octadecadienoic acid (Z,Z)-,2-hydroxy-1-(hydroxymethyl)ethyl ester linoleic acid monoacylglycerol 9,12,15-OCTADECATRIENOIC ACID, (Z,Z,Z)- Glyceryl 2-linoleate 9Z,12Z,15Z-octadecatrienic acid 2-monolinoleoylglycerol 9Z,12Z,15Z-Octadecatrienoic acid (9Z,12Z,15Z)-9,12,15-Octadecatrienoic acid MFCD00065720 a-Linolenic Acid octadecatrienoic acid 9,12,15-octadecatrienoic acid alpha-linolenic acid (all-Z)-9,12,15-Octadecatrienoic acid (9Z,12Z)-1,3-dihydroxypropan-2-yl octadeca-9,12-dienoate Linolenic acid C18:3 (9,12,15-cis all) 2-Linoleoylglycerol 9,12,15-Octadecatrienoic acid, (9Z,12Z,15Z)- (9CI) |
Description | α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1]. |
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Related Catalog | |
Target |
PI3K Akt |
In Vitro | α-Linolenic acid converses into the longer chain fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)[1]. |
In Vivo | α-Linolenic acid (50, 100, 250 mg/kg; for 10 days) can completely inhibit collagen- and adrenaline-induced thrombosis in mice at 250 mg/kg[1]. α-Linolenic acid (35, 70, 175 mg/kg) suppresses A-V thrombus formation in rats (weighing at 250 ~ 300 g)[1]. α-Linolenic acid (70 or 175 mg/kg) inhibits collagen stimulated platelet aggregation in rats[1]. Animal Model: Mice weighing at 18 ~ 22 g[1] Dosage: 50, 100, 250 mg/kg Administration: For 10 days Result: Completely inhibited collagen- and adrenaline-induced thrombosis at 250 mg/kg. |
References |
Density | 0.9±0.1 g/cm3 |
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Boiling Point | 443.4±0.0 °C at 760 mmHg |
Melting Point | -11 °C(lit.) |
Molecular Formula | C18H30O2 |
Molecular Weight | 278.430 |
Flash Point | 275.7±14.4 °C |
Exact Mass | 278.224579 |
PSA | 37.30000 |
LogP | 6.50 |
Vapour Pressure | 0.0±2.3 mmHg at 25°C |
Index of Refraction | 1.491 |
Storage condition | 2-8°C |
Water Solubility | INSOLUBLE |
Personal Protective Equipment | Eyeshields;Gloves |
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Hazard Codes | F;Xi |
Risk Phrases | R36/37/38 |
Safety Phrases | S26-S36 |
RIDADR | NONH for all modes of transport |
WGK Germany | 1 |
HS Code | 2916190090 |
~95% 463-40-1 |
Literature: Sandri; Viala Synthesis, 1995 , # 3 p. 271 - 275 |
~% 463-40-1 |
Literature: DSM IP ASSETS B.V. Patent: US2012/277772 A1, 2012 ; |
~% 463-40-1 |
Literature: Cheng, Jin-Tang; Li, Yan; He, Juan; Li, Xing-Yao; Wu, Xing-De; Shao, Li-Dong; Dong, Liao-Bin; Deng, Xu; Gao, Xiu; Peng, Li-Yan; Cheng, Xiao; Zhao, Qin-Shi Helvetica Chimica Acta, 2012 , vol. 95, # 7 p. 1158 - 1163 |
~% 463-40-1 |
Literature: Baruah, Putul; Baruah,Nabin C.; Sharma, Ram P.; Baruah, Jogendra N.; Kulanthaivel, Palianappan; Herz, Werner Phytochemistry (Elsevier), 1983 , vol. 22, # 8 p. 1741 - 1744 |
~% 463-40-1 |
Literature: Sashidhara, Koneni V.; Singh, Suriya P.; Misra, Sweta; Gupta, Jyoti; Misra-Bhattacharya, Shailja European Journal of Medicinal Chemistry, 2012 , vol. 50, p. 230 - 235 |
~% 463-40-1 463-40-1 |
Literature: Erdmann; Bedford Chemische Berichte, 1909 , vol. 42, p. 1333 Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1910 , vol. 69, p. 79 |
~% 463-40-1 463-40-1 |
Literature: Hazura Monatshefte fuer Chemie, 1887 , vol. 8, p. 267 Full Text Show Details Erdmann; Bedford Chemische Berichte, 1909 , vol. 42, p. 1333 Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1910 , vol. 69, p. 79 |
Precursor 6 | |
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DownStream 10 | |
HS Code | 2916190090 |
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Summary | 2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0% |