294648-66-1

294648-66-1 structure

294648-66-1 structure

Name: ADAMTS-5-IN-2
Chemical Name: ADAMTS-5-IN-2
CAS Number: 294648-66-1
Molecular Formula: C₁₇H₁₅N₃OS
Molecular Weight: 309.39
Catalog: Research Areas Inflammation/Immunology
Create Date: 2023-05-19 11:38:32
Modify Date: 2024-04-05 01:49:36
ADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC50 value of 0.71 µM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis[1][2].

Name	ADAMTS-5-IN-2

Description	ADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC50 value of 0.71 µM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
References	[1]. Bompiani KM, et al. High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes. ACS Comb Sci. 2016 Aug 8;18(8):461-74. [2]. Matthew G. Bursavich; et al. 5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorganic & Medicinal Chemistry Letters. 2007, 17(20), 5630-5633.

Molecular Formula	C₁₇H₁₅N₃OS
Molecular Weight	309.39