2738381-47-8
2738381-47-8 structure
- Name: Anti-infective agent 5
- Chemical Name: Anti-infective agent 5
- CAS Number: 2738381-47-8
- Molecular Formula: C18H13N5O3
- Molecular Weight: 347.33
- Catalog: Research Areas Infection
- Create Date: 2022-10-11 13:57:24
- Modify Date: 2024-04-06 17:07:14
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Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection[1].
| Name | Anti-infective agent 5 |
|---|
| Description | Anti-infective agent 5 (compound 74) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.10 μM. Anti-infective agent 5 effectively reduces parasite burden in vivo. Anti-infective agent 5 can be used for the research of infection[1]. |
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| Related Catalog | |
| Target |
IC50: 0.10 μM (Trypanosoma cruzi)[1] |
| In Vitro | Anti-infective agent 5 (0.1 nM-100 μM; 48 h) shows antitrypanosomal activity against T. cruzi amastigotes in 3T3 cells with an IC50 value of 0.10 μM[1]. Cell Cytotoxicity Assay[1] Cell Line: 3T3 cell line Concentration: 0.1 nM-100 μM Incubation Time: 48 hours Result: Showed activity against 3T3 cells with an CC50 value of ＞37 μM. |
| In Vivo | Anti-infective agent 5 (50 mg/kg; p.o. twice daily for five days) reduces the parasite burden in bioluminescent T. cruzi mouse model[1]. Animal Model: BALB/c mice with bioluminescent T. cruzi CL Brener parasites infection[1] Dosage: 50 mg/kg Administration: Oral gavage; 50 mg/kg twice daily for five days Result: Showed a reduction in parasite burden of >98-99% with no significant adverse effects observed in mice. |
| References |
| Molecular Formula | C18H13N5O3 |
|---|---|
| Molecular Weight | 347.33 |